Host-pathogen interactions in clostridial myonecrosis

这个项目将展示引起气性坏疽的细菌如何在感染中与宿主细胞相互作用。我们将在小鼠疾病模型中检测来自宿主和病原体的基因表达。目的是确定在感染病变中差异调节的细菌基因的影响，宿主和病原体的基因表达在整个感染过程中是如何被调节的，以及宿主途径在控制感染过程中的作用。

This project will show how the bacteria that cause gas gangrene interact with host cells in an infection. We will examine the expression of genes from both the host and the pathogen in a mouse disease model. The aims are to determine the impact of bacterial genes that are differentially regulated in an infected lesion, how gene expression of both the host and pathogen is modulated throughout the course of an infection and the role of host pathways in controlling the infection process.