How a multidrug resistant bacterial pathogen has become pandemic

具有抗生素耐药性的大肠杆菌ST131的大流行传播是一个重大的人类健康问题。ST131是全球尿路和血液感染的主要原因。该项目将使用先进的遗传学和动物感染模型来了解ST131的特征，这些特征助长了ST131在全球的主导地位。这一结果将揭开ST131持续存在并导致重复感染的分子机制，并指导新的精准药物疗法的发展。

The pandemic spread of antibiotic resistant E. coli ST131 is a major human health problem. ST131 is the globally dominant cause of urinary tract and bloodstream infections. This project will use advanced genetics and animal infection models to understand the features of ST131 that have fueled its global dominance. The outcomes will unravel the molecular mechanisms that enable ST131 to persist and cause repeat infection, and guide the development of new precision medicine therapeutics.