Training Program in Nephrology Research

描述(由申请人提供)： 这项提议是为了支持犹他大学健康科学中心的一个肾脏学培训项目，该项目将在五年内为四个博士后职位提供培训，其中包括博士S和医学博士S。肾脏病培训计划由几组广泛互动的研究人员组成。有14名导师和18名合作者参与其中。许多研究人员分布在成人和儿童肾脏病学部，但也有研究人员在人类遗传学、病理学、医学信息学、生理学、神经生物学和解剖学、生物工程学以及心脏病学、内分泌学、肺病学和流行病学系。主要研究小组包括：1)集合管生物学，涉及内皮素、一氧化氮、前列腺素、活性氧和嘌呤能系统在集合管和髓质功能调节中的作用，在健康和高血压中的作用；2)急性肾功能衰竭，研究缺血、药物和毒素诱导的急性肾功能衰竭模型的病理生理学；3)慢性肾功能衰竭的进展，研究糖尿病肾病、慢性环孢素A肾病和系膜增生性肾炎模型中肾脏纤维化的机制；4)肾脏发育，重点关注相关的转录调控途径；5)ESRD与慢性肾功能不全，包括结局分析、干预和病理生物学。学员可以参与临床或基础研究项目。所有受训人员都将体验一种多层面的培训方法。临床研究实习生参加K-30计划，在该计划中，他们接触到各种各样的临床研究项目。基础研究实习生经历了一个庞大的教职员工群体，他们的研究兴趣互补。所有受训人员至少要花两年时间从事研究工作。

DESCRIPTION (provided by applicant): This proposal is for support of a Nephrology Training Program at the University of Utah Health Sciences Center for four postdoctoral positions, involving both Ph.D.'s and M.D.'s, over a five year period. The Nephrology Training Program consists of several groups of investigators who extensively interact. There are 14 preceptors and 18 collaborators involved. Many investigators are located within the Divisions of Adult and Pediatric Nephrology, however there are investigators in the Departments of Human Genetics, Pathology, Medical Informatics, Physiology, Neurobiology and Anatomy, and Bioengineering, as well as the Divisions of Cardiology, Endocrinology, Pulmonary and Epidemiology. The major research groups are organized into those investigating: 1) collecting duct biology, involving the roles of endothelins, nitric oxide, prostaglandins, reactive oxygen species and the purinergic system in regulating collecting duct and medullary function in health and in hypertension; 2) acute renal failure, studying the pathophysiology of ischemic, drug-induced, and toxin-induced acute renal failure models; 3) progression of chronic renal failure, studying the mechanisms of renal fibrosis in models of diabetic nephropathy, chronic cyclosporine nephropathy, and mesangial proliferative GN; 4) renal development, emphasizing relevant transcriptional regulatory pathways; and 5) ESRD and chronic renal insufficiency, involving analysis of outcomes, interventions and pathobiology. Trainees can become involved in either clinical or basic research projects. All trainees will experience a multidimensional approach to their training. Clinical research trainees are enrolled in the K-30 program wherein they are exposed to a wide variety of clinical research projects. Basic researcher trainees experience a large faculty group with complementary research interests. All trainees spend at least two years devoted to research.