University of Kansas Training Grant in Nephrology

描述(由申请人提供)： KUMC肾脏病研究金计划的主要目标是招募和培训有潜力发展为肾脏病领域独立研究人员的博士后研究员。该培训计划旨在为医生或医学科学家的研究生涯做好准备，要么是拥有执行基于结果的研究和/或临床试验所需技能的临床调查人员，要么是将分子生物学的进步转化为临床实践的基础科学家。为了实现这一目标，培训计划为博士后研究员提供了一个结构化的环境，让他们学习肾脏的正常生理学和病理生理学，并参与由NIH资助的研究人员领导的个性化指导性研究计划，以研究肾脏疾病和相关代谢紊乱的发病机制、治疗和健康结果。我们项目的一个主要优势是肾脏研究所，这是一个致力于肾脏研究领域的多学科中心。KUMC肾脏研究所的肾脏研究和患者护理项目创造了一个环境，促进生物医学研究人员和转化性研究项目的交叉培训。在研究肾脏病学的两到三年培训期间，学员可以选择临床研究培训计划或基础研究培训计划。目前的机会领域包括人类疾病的小鼠遗传模型、转录调控机制、遗传性肾脏疾病、慢性肾脏疾病中的激素和矿物质代谢异常、信号转导、运输生理学、肾脏发育和足细胞生物学。培训的目的是促进对肾脏疾病和代谢并发症的生化、生理和分子生物学方法的理解、设计和使用；以及熟练掌握实验室和临床研究技术。完成该计划的个人将能够进行独立的研究，并将研究成果转化为具有临床意义的重要进展。

DESCRIPTION (provided by applicant): The primary objective of the KUMC Nephrology Fellowship Program is to recruit and train postdoctoral fellows who demonstrate potential for developing into independent investigators in the field of Nephrology. The training program is designed to prepare physicians or medical scientists for research careers as either clinical investigators with the skills necessary to perform outcomes-based studies and/or clinical trials, or basic scientists who will translate advances in molecular biology to clinical practice. To accomplish this, the training program provides a structured environment for postdoctoral fellows to learn normal physiology and pathophysiology of the kidney and to participate in individualized mentored research programs led by NIH-funded investigators to study the pathogenesis, treatment and health outcomes of kidney diseases and related metabolic disorders. A major strength of our program is the Kidney Institute, a multidisciplinary center dedicated to the field of kidney research. A program in renal research and patient care at the Kidney Institute at KUMC creates an environment that fosters cross-training of biomedical researchers and translational research programs. During the two to three training years devoted to investigative nephrology, trainees can choose between the Clinical Research Training Program or the Basic Research Training Program. Current areas of opportunity include mouse genetic models of human diseases, transcriptional control mechanisms, hereditary kidney diseases, hormonal and mineral metabolism abnormalities in chronic kidney disease, signal transduction, transport physiology, renal development and podocyte biology. Training is aimed at promoting understanding, design, and use of biochemical, physiological and molecular biological approaches to kidney disorders and metabolic complications; and proficiency in laboratory and clinical investigation techniques. Individuals who complete the program will be capable of independent investigation and translating research accomplishments into important advances with clinical relevance.