Institutional Research Cancer Epidemiology Fellowship

描述（由申请人提供）：本提案是重新提交的申请，用于在约翰霍普金斯彭博公共卫生学院进行癌症流行病学、预防和控制培训计划的NRSA机构研究资助的5年续期（24-28年）。该计划的使命是培养博士前学生和博士后研究员成为领导者在推进癌症的原因，包括遗传和可改变的因素，以及如何预防癌症的知识的前沿提供了更好地了解癌症相关的行为和识别新的标志物在人口为基础的研究癌症的早期检测。该计划的目标是为学员创造一个丰富和互动的环境，由公共卫生学院，Kimmel癌症中心和约翰霍普金斯医疗机构的观察，基础和临床科学家进行的高度创新，富有成效和协作的癌症研究增强。该计划的主题体现在3个互补的培训轨道：1）癌症病因学和预防; 2）癌症的遗传流行病学;和3）癌症控制。7个博士前和4个博士后学员追求一个有重点的计划，包括跨轨道的共享元素：教学课程的实质性和方法论问题内和跨学科和研究伦理;互动信息交流，包括研究进展，研讨会和专题讨论会;教学，沟通，授予写作经验;通过流行病学和实验室癌症研究计划（pre-doc）对现有数据集进行统计分析和短期轮换的实践经验;在从事导师的指导下进行博士前或博士后研究;以及针对具体项目的教育、研究和职业指导。我们强调开发和测试新的生物学假设和跨学科合作的重要性。通过共享的元素，我们的学员接触到当前的问题，如转化研究，分子流行病学，新出现的癌症风险因素，癌症研究和筛查的方法学问题，癌症差异，烟草控制，肥胖/能量平衡，炎症，以及流行病学在风险评估和公共政策中的应用。修订后的方案建立在一个长期跟踪记录的方案基础上，根据现任和前任学员、外部顾问和同行评审员的评估作出了重大修改。该方案有19名负责初级指导的导师。另有39名附属教师以书面形式承诺提供特定癌症部位，生物统计学和基于实验室的暴露评估方面的专业知识;他们聚集在一起，为学员的经验带来广度和深度，并满足他们随着科学进步而不断变化的需求。一个指导委员会负责学员的选择和监测，并随着这些领域的进展完善培训方案。该提案记录了培训和指导的明确记录;在过去10年中任命的23名博士前和10名博士后学员在癌症研究事业上取得了成功。从大量的申请者中，我们招募了代表不同背景的最佳候选人。总之，该计划旨在为学员提供进行最高水平的最先进的合作癌症研究所必需的多学科背景，培养创新思维和教学和沟通的能力，并使他们成为国家人口为基础的癌症研究议程的领导者。

DESCRIPTION (provided by applicant): This proposal is a resubmission of an application for a 5-year renewal (Years 24-28) of an NRSA Institutional Research Grant for the training program in Cancer Epidemiology, Prevention, and Control at the Johns Hopkins Bloomberg School of Public Health. The program mission is to train pre-doctoral students and post-doctoral fellows to become leaders at the forefront of advancing the knowledge of the causes of cancer, including genetic and modifiable factors, and how to prevent cancer by providing a better understanding of cancer-related behaviors and identifying new markers for the early detection of cancer in population-based studies. The program goal is to create a rich and interactive environment for trainees augmented by the highly innovative, productive, and collaborative cancer research conducted by observational, basic, and clinical scientists at the School of Public Health, Kimmel Cancer Center, and Johns Hopkins Medical Institutions. The program themes are embodied in the 3 complementary training tracks: 1) Cancer Etiology and Prevention; 2) Genetic Epidemiology of Cancer; and 3) Cancer Control. The 7 pre- and 4 post-doctoral trainees pursue a focused program consisting of shared elements across the tracks: didactic courses in substantive and methodologic issues within and across disciplines and research ethics; interactive information exchange including research in progress, seminars, and symposium; teaching, communication, grant writing experiences; practical experiences of a statistical analysis of an existing dataset and short rotations through epidemiology and laboratory cancer research programs (pre-doc); pre- or post-doctoral research under an engaged preceptor; and program-specific education, research, and career mentoring. We stress the importance of developing and testing novel biologically based hypotheses and collaborating across disciplines. Via the shared elements, our trainees are exposed to current issues, such as translational research, molecular epidemiology, emerging risk factors for cancers, methodologic issues in cancer research and screening, cancer disparities, tobacco control, obesity/energy balance, inflammation, and use of epidemiology in risk assessment and public policy. The revised program builds on a program with a long track record, with major changes made in response to evaluations from current and former trainees, an external advisor, and peer reviewers. The program has a core of 19 preceptors who are responsible for primary mentoring. An additional 39 affiliated faculty have committed in writing to providing expertise in specific cancer sites, biostatistics, and laboratory based exposure assessment; they were assembled to bring breadth and depth to the trainees' experiences and to meet their changing needs as science advances. A Steering Committee is responsible for trainee selection and monitoring, and refinement of the training program as these fields progress. The proposal documents a clear record of training and mentorship; the 23 pre- and 10 post-doctoral trainees appointed in the past 10 years have cancer research career success. From a large pool of applicants, we recruit the best possible candidates who represent diverse backgrounds. In summary, the program is designed to provide trainees with the multidisciplinary background essential to conduct the highest caliber state-of-the-art collaborative cancer research, to nurture innovative thinking and the ability to teach and communicate, and to prepare them to be leaders in the Nation's population-based cancer research agenda.