Resubmission (due to requested amendments): New models for spatially structured populations

由于对种群结构的内在兴趣和对人类序列变异的现实统计模型的需要，人们对理解空间扩展种群的遗传多样性有很大的兴趣。目前的分析主要假设种群以恒定密度生活在晶格点上。然而，真实的人口并不是这样细分的，也不是长期稳定的。事实上，遗传多样性主要是由大规模人口流动形成的。该项目的主要目的是调查短期和长期波动对进化种群的相对影响。这将在空间扩展种群进化的新数学模型框架内完成，该模型明确包含大规模波动。它包括经典的岛屿模型和垫脚石模型作为特殊情况，但也可以表述为描述连续体中的种群进化。通过分析和模拟相结合，我们的目标是确定可以从空间分布的种群中收集的遗传数据中测量的远程波动的特征。

There is great interest in understanding genetic diversity in spatially extended populations, bothbecause of the intrinsic interest in population structure and because of the need for realistic statistical models of human sequence variation. Current analyses mainly assume that populationsare restricted to live at points of a lattice at constant density. Yet real populations are not subdivided in this way and nor are they stable over long times. Indeed genetic diversity is shaped primarily bylarge-scale population movements.The principal aim of this project is to investigate the relative effects of short and long range fluctuations on evolving populations. This will be done in the framework of a new mathematical model for evolution in spatially extended populations which explicitly incorporates large scale fluctuations. It includes the classical island and stepping stone models as special cases, but can also be formulated to describe populations evolving in a continuum. Using a combination of analysis and simulation we aim to identify signatures of long-range fluctuations which could be measured in genetic data collected from spatially distributed populations.