Multigenotypic Aged Mouse Colony

目前和计划中的实验使用啮齿动物来模拟人类的衰老过程和与年龄相关的疾病，需要确定的基因型和受控的环境和健康状况的动物。只有对遗传和环境变量进行细致、长期的控制，才有可能维持相关的动物模型，用于研究衰老过程中的许多生物和行为过程。因此，持续供应遗传定义、特征良好的近交和杂交实验动物对于衰老研究计划至关重要。本项目的目的是开发、维持和分发一个由NIA指定基因型的老年小鼠组成的常设群体，供研究人员在衰老研究中使用。

Current and projected experiments using rodents to model the aging processes and age-related diseases in humans require animals of defined genotype and controlled environmental and health status. Only with the meticulous, long-term control of genetic and environmental variables is it possible to maintain relevant animal models that may be used to study many ofthe biological and behavioral processes in aging. Therefore, a continuous supply ofgenetically defined, well characterized inbred and hybrid laboratory animals is essential for a program of research on aging. The purpose of this project is to develop, maintain and distribute a standing colony of aged mice of NIA-specified genotypes for use by investigators in studies of aging.