SEARCH for Diabetes in Youth 2: South Carolina Center

这项建议建立在一个为期五年的研究项目，青年糖尿病的搜索，其标准化数据， 收集工作，经验丰富的调查员团队，建立了病例确定基础设施， 多元化的人口基础。这是一个来自六个临床试验机构的通用集成应用程序， 决定继续并扩大联合国儿童基金会开展的工作，以解决以下具体问题 研究目的：目的1：确定2006-2009年新发病例年龄小于 20年，以估计青年糖尿病发病率的时间趋势; 目标2：对2002-2005年已被招募到卫生部的事件进行纵向跟踪， 根据临床和生化因素记录新诊断DM的演变; 目标3：完成SEARCH前五年开始的分析，扩大护理质量的范围 评估应包括更广泛定义的概念和质量衡量标准; 目的4：开发和验证青年DM类型的简单和低成本病例定义和分类 可以用于公共卫生监测。 这项建议的新奇包括它的全面性，它将主要和及时的方面结合在一起， 儿童期糖尿病研究：一项流行病学研究，在美国是独一无二的， 青年糖尿病发病率;青年糖尿病自然史的病理生理学组成部分; 护理过程和生活质量的研究;以及对糖尿病病例分类的公共卫生观点， 青年这项研究对公共卫生至关重要，因为它将提供有关是否和 DM在美国不同种族/民族的年轻人中增加了多少， 糖尿病对身体健康的影响，包括并发症，以及关于糖尿病治疗质量的有价值的数据。 关心这些年轻人的生活质量。南卡罗来纳州临床研究中心的特殊优势包括： 1)研究人员在国家科学领导方面的丰富经验，包括在国家科学研究领域的领导经验。 出版物和其他辅助研究; 2）高度稳定和经验丰富的当地诊所工作人员， 确保项目的有效运作; 3）成功地确定和纳入非洲人， 美国青年，包括许多生活在医疗服务不足的社区。

This proposal builds upon a five year research project, SEARCHfor Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which Droposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of DM in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM accordingto clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCHand expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth; a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ ethnic groups in the United States, about how DM impacts on the physical health, including complications, as well as valuable data regarding the quality of care and the quality of life of these youth. The particular strengths of the South Carolina clinical site include: 1) extensive experience of the investigators in national scientific leadership including leadership in SEARCH publications and SEARCH ancillary studies; 2) a highly stable and experienced local SEARCH clinic staff to ensure efficient operation of the SEARCH project; and 3) success in identification and inclusion of African American youth, including many living in medically underserved communities.