CORE--MOUSE

核心B是转基因老鼠资源核心。这三个项目都将广泛利用 转基因小鼠，用于他们拟议的实验。动物的集中定位，理性 控制和共享育种种群，集中进行基因分析将最大限度地提高效率 并最大限度地减少与生产拟议实验所需的小鼠相关的成本。特定的 核心B的活动包括(1)协助产生额外的转基因小鼠模型， (2)种质资源的建立与维护；(3)转基因材料的产生与基因分型 和/或基因敲除小鼠，(4)定时妊娠的产生和收集，(5)寄养，断奶和 实验动物的储存，(6)转基因小鼠模型的分发，以及(7)交付 将实验动物送到适当的实验室使用。核心人员已经在所有方面都受到了良好的培训 将提供的服务的各个方面。鉴于对转基因动物的严重依赖， 核心B对计划项目拨款申请的成功的重要性怎么强调都不为过。

Core B is the Genetically Modified Mouse Resources Core. All three projects will make extensive use of genetically modified mice for their proposed experiments. Centralized localization of the animals, rational control and sharing of the breeding stocks, and centralization of genotype analyses will maximize efficiency and minimize costs associated with the production of the mice needed for the propose experiments. Specific activities of Core B include (1) Assistance in the generation of additional genetically modified mouse models, (2) Establishment and maintenance of breeding stocks, (3) Generation and genotype analysis of transgenic and/or knock-out mice, (4) Generation and collection of timed pregnancies, (5) Fostering, weaning and storage of the experimental animals, (6) Distribution of genetically modified mouse models, and (7) Delivery of experimental animals to the appropriate laboratory for use. Core personnel are already well-trained in all aspects of the services to be provided. Given the heavy reliance on genetically modified animals, the importance of Core B to the success of the Program Project Grant application cannot be overstated.