Human Tissue and Organ Resource for Research

国家疾病研究的人体组织和器官研究计划 Interchange仅致力于获取和提供用于研究目的的人体组织。这些 组织和器官是HTOR和该计划提供服务的绝大多数研究项目所必需的 显然与促进人类健康有关。HTOR的长期目标是增加数量， 可供研究的人体研究组织的多样性和质量。收集、准备和 组织的保存必须按照研究人员指定的材料方案进行 对科学家有用。这些材料的获取需要一个广泛的全国性网络 收购网站，如医院病理和外科服务、眼科和组织库以及器官 采购组织。HTOR独特的系统确保为定制协议采购的组织 以及时的方式提供给适当的研究目的地。数量、质量和多样性 运送给调查人员的组织的数量取决于三个关键变量：来源的数量和类型 与HTOR合作，HTOR的内部系统，以及以下研究请求的数量和类型 HTOR是从研究人员那里收到的。拟议供资期间的具体目标侧重于加强 HTOR计划的这三个分支(信息源、信息系统和研究人员)。HTOR将起作用 增加现有来源的能力并增加新的来源，以增加组织数量和多样性 (目标1/来源)；升级HTOR的内部系统(计算机硬件、软件和数据管理) 改进数据捕获和分析，并升级HTOR网站以增加来源和研究人员 获得HTOR资源(目标2/系统)；并与研究社区密切合作，以满足现有 以及对人体研究组织的新需求(目标3/研究人员)。此外，HTOR将继续 采购和分发艾滋病毒阳性组织的专门方案(目标4)，这一目标也是一致的 与HTOR的长期目标保持一致。

The Human Tissues and Organs for Research (HTOR) program of the National Disease Research Interchange is dedicated solely to accessing and providing human tissues for research purposes. These tissues and organs are essential for the great majority of research projects served by HTOR and the program is clearly relevant to advancing human health. HTOR's long-term objective is to increase the quantity, diversity, and quality of human research tissues available for research. The collection, preparation, and preservation of the tissues must be performed according to researcher-specified protocols for the materials to be useful to scientists. The acquisition of these materials requires an extensive national network of acquisition sites such as hospital pathology and surgical services, eye and tissue banks, and Organ Procurement Organizations. HTOR's unique systems ensure that tissues procured for customized protocols are delivered in a timely manner to the appropriate research destinations. The quantity, quality and diversity of tissues shipped to investigators is a function of three critical variables: the number and types of Sources working with HTOR, the internal systems of HTOR, and the number and types of research requests that HTOR receives from Researchers. The Specific Aims of the proposed funding period focus on strengthening these three arms of the HTOR program (Sources, Information Systems, and Researchers). HTOR will work to increase the capabilities of existing sources and add new sources to increase tissue quantity and diversity (Aim 1/Sources); upgrade HTOR's Internal Systems (computer hardware, software, and data management) to improve data capture and analysis, and upgrade the HTOR Web Site to increase Source and Researcher access to HTOR resources (Aim 2/Systems); and work closely with the research community to fulfill existing and emerging needs for human research tissue (Aim 3/Researchers). In addition, HTOR will continue a specialized program for procuring and distributing HIV positive tissues (Aim 4), a goal that is also consistent with HTOR's long-term objective.