SWAN Sleep Study II: Pittsburgh

女性在中年期间睡眠障碍增加，部分原因是年龄本身的影响，但也有原因 可能部分是由于更年期过渡，即荷尔蒙、症状和出血的变化 发生在更年期过渡期间。这项修订后的提案(睡眠II)将纵向延长 目前资助的、多地点、多种族的中年妇女睡眠横断面研究(睡眠I期)。在《睡眠I》中， 对370名绝经前、围绝经期和绝经后的中年高加索人进行了现场检查， 非裔美国人和中国女性来自妇女健康研究的七个研究站点中的四个 全国(Swan，一项关于更年期和衰老的纵向研究)，使用家庭多导睡眠图， 每日日记和活动记录仪，以及自我报告睡眠问卷。在睡眠II中，使用协调的R01 在这一机制下，将对同一妇女样本进行第二次实地检查(谁将是 年龄51-62岁)，采用相同的程序。一个被广泛引用的启发式模型 睡眠障碍的病理生理学将应用于这些纵向数据来评估发展 在这个多种族的女性样本中，与更年期相关的睡眠障碍的研究。该模型将急性 睡眠障碍对诱因和诱发因素的综合影响，以及持续的睡眠 慢性睡眠障碍不仅是急性压力源，也是永久性因素。 这项对绝经过渡期睡眠的纵向评估的具体目标是 确定潜在的：1)诱因(种族、社会经济地位低、体力活动水平低、 体重指数高、吸烟、睡眠问题史、健康状况差)；2)诱发因素 (血管运动症状、新的不良生活事件、卵泡刺激素快速增加) 过渡期间的睡眠障碍；3)永久性因素(睡眠卫生差，态度失调 以及关于睡眠的信念、夜间高度唤醒、种族)在 4)睡眠障碍对随后早期健康状况的不利影响。 绝经后(代谢状况恶化，高血压增加，生活质量恶化，以及 增加了症状报告。) 这项研究的公共卫生相关性是为了更好地了解女性睡眠的变化 来自不同的种族和社会经济背景，并确定睡眠问题的风险因素。这个 结果可以为初级预防提供信息，以了解更年期睡眠导致的不良健康后果 骚乱。 这是对AG19362的修订应用。

Sleep disruptions increase during mid-life in women, due in part to the effects of age itself, but also possibly due in part to the menopausal transition, i.e. changes in hormones, symptoms, and bleeding that occur during the menopausal transition. This revised proposal (Sleep II) will extend longitudinally the currently funded, multi-site, multi-ethnic cross-sectional study of sleep in midlife women (Sleep I). In Sleep I, field-based examinations were conducted with 370 midlife pre-, peri- and postmenopausal Caucasian, African-American, and Chinese women from four of seven study sites from the Study of Women's Health Across the Nation (SWAN, a longitudinal study of menopause and aging), using in-home polysomnography, daily diaries and actigraphs, and self-report sleep questionnaires. In Sleep II, using a Coordinated R01 mechanism, a second field-based examination will be conducted on the same sample of women (who will be aged 51-62 years), incorporating the same procedures. A widely-cited heuristic model of the pathophysiology of sleep disturbances will be applied to these longitudinal data to evaluate the development of menopause-related sleep disturbances in this multi-ethnic sample of women. This model attributes acute sleep disturbances to the combined effects of predisposing and precipitating factors, and persistence of chronic sleep disturbances beyond the acute stressor to perpetuating factors. The specific aims for this longitudinal assessment of sleep through the menopausal transition are to identify potential: 1) predisposing factors (race, low socioeconomic status, low levels of physical activity, high body mass index, smoking, history of sleep problems, poor health status); 2) precipitating factors (vasomotor symptoms, new adverse life events, rapid increases in follicle stimulating hormone) for acute sleep disturbances during the transition; 3) perpetuating factors (poor sleep hygiene, dysfunctional attitudes and beliefs about sleep, heightened arousal at night, race) for chronic sleep disturbances during the transition; and 4) adverse effects of sleep disturbances on subsequent health status during the early postmenopause (worsening metabolic profile, increased hypertension, worsening of quality of life, and increaed symptom reporting.) The public health relevance of this research is to understand better the changes in the sleep of women from different racial and socioeconomic backgrounds and identify risk factors for sleep problems. The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. This is a revised application of AG19362.