Clinical

临床核心是基础科学、临床、行为学和流行病学之间的接口 调查人员和艾滋病患者。通过建立多个诊所， 综合性临床数据库--社区和国际的临床标本库 外展项目，以及几个侧重于常见艾滋病毒相关并发症的特别方案 和合并感染，临床核心是所有与患者相关的活动的中心，范围从 进行临床试验以提供临床标本和临床结果信息 100多名UAB CFAR调查人员和世界各地的调查人员。《公约》的具体目标 临床核心是：1)为与急性呼吸综合征相关的临床和转化性研究提供基础设施 和早期艾滋病毒感染；儿童、青少年和患有艾滋病毒/艾滋病的成人；以及与艾滋病毒有关的 疫苗。2)在所有阶段扩大学生和卫生保健工作者的教育机会 培训和实践，以发展与临床设计、道德行为和分析相关的技能 研究。3)维护和更新1917年临床数据库--用于执行临床、 药物经济学和心理社会结果研究，并确定潜在的研究对象--以及 参与CFAR-综合临床系统网络(C-NICS)。4)收集、处理、存储和 将高质量的血液和组织样本从特征良好的患者通过 综合临床标本库。5)提供药理分析利用 创新的、最先进的方法。6)促进跨学科计划，以更好地了解 HIV/抗逆转录病毒治疗代谢并发症的发病机制和处理 几种重要的艾滋病毒共病原体(特别是性传播疾病、乙肝和丙型肝炎)。7)开展外展 针对艾滋病毒高危人群的教育、预防和治疗机会的方案 以及它的复杂性。此应用程序描述了UAB CFAR方案的最新发展 反映艾滋病流行的多样化和不断变化的面貌--日益重视计算机化 患者记录、研究数据库和结果研究；加强国际研究协作 与急性和慢性艾滋病毒感染有关的努力；以及新的跨学科方案，重点是 重要的感染共病原体和最近承认的与治疗相关的并发症。维护 这一广泛的相互关联和协同作用的项目只有通过提供联合审计才有可能 CFAR基础设施、组织和资源。

The Clinical Core serves as an interface between basic science, clinical, behavioral, and epidemiologic investigators and patients with HIV disease. Through the establishment of multiple clinics, a Comprehensive Clinical Database, a Clinical Specimen Repository, community and international outreach projects, and several special programs focused on common HIV-related complications and co-infections, the Clinical Core serves as a hub for all patient-related activities, ranging from the conduct of clinical trials to provision of clinical specimens and clinical outcome information to the 100+ UAB CFAR investigators and investigators around the world. The SPECIFIC AIMS of the Clinical Core are to: 1) Provide infrastructure for clinical and translational research related to acute and early HIV infection; children, adolescents, and adults with established HIV/AIDS; and HIV-related vaccines. 2) Expand educational opportunities for students and health care workers at all phases of training and practice to develop skills related to the design, ethical conduct, and analysis of clinical research. 3) Maintain and update the 1917 Clinic Database -- used to perform clinical, pharmacoeconomic, and psychosocial outcome studies and to identify potential research subjects -- and participate in the CFAR-Network of Integrated Clinical Systems (C-NICS). 4) Collect, process, store, and distribute high-quality blood and tissue specimens from well-characterized patients to investigators via a Comprehensive Clinical Specimen Repository. 5) Provide pharmacologic analyses utilizing innovative, state-of-the-art methodologies. 6) Foster interdisciplinary programs to better understand the pathogenesis and management of metabolic complications of HIV/antiretroviral therapies as well as several important HIV co-pathogens (especially STDs, Hepatitis B and C). 7) Provide outreach programs targeting education, prevention, and treatment opportunities for special groups at risk for HIV and its complications. This application describes recent UAB CFAR programmatic developments that reflect the diverse and changing face of the AIDS epidemic - an increasing emphasis on computerized patient records, research database, and outcomes research; increasing international research collaborative efforts related to acute and chronic HIV infection; and new interdisciplinary programs focused on critically important infectious co-pathogens and recently recognized treatment-related complications. Maintaining this broad array of inter-connected and synergistic projects is possible only through the provision of UAB CFAR infrastructure, organization, and resources.