Clinical and Population Sciences

加州大学旧金山分校-GIVI CFAR的主要重点是艾滋病毒相关研究，这既是翻译的，也是 多学科。这项研究通常包括以人体为观察单位的研究 并在其中测量复杂的生物、行为和临床参数，通常是纵向的 举止。人类受试者研究的一个前提是与之直接互动并具有示范性 疾病和非疾病研究对象的特征。因此，该计划的总体目标是 临床和人口科学的核心将是整合人口科学的流行病学和 生物统计学与艾滋病毒医学的临床科学，以促进与艾滋病毒的相互作用和表征 人类受试者以及从他们那里获得的数据和生物标本的分析。实现这一点 目标反过来促进以实验室为基础的和以人类为基础的受试者之间的多学科合作 是研究人员，也是翻译研究的必要条件。因此，委员会的具体目标是 核心将是通过以下方式支持以人类受试者为基础的创新艾滋病毒相关研究： 1.通过咨询提供与艾滋病毒/艾滋病研究有关的临床和人口学方面的专业知识 关于研究问题的概念、研究设计、数据管理、生物统计分析以及 数据解释； 2.作为CFAR调查人员的资源交换中心，这些调查人员寻求通过 在旧金山的许多大型和全国性的艾滋病毒感染和高危研究中获得的数据 个人； 3.管理当代独特的艾滋病毒感染成人前瞻性观察队列， 为翻译研究人员提供来自以下对象的各种生物样本 在临床、行为和流行病学参数方面特征良好； 4.为新设计的预期人体受试者研究提供有效进行的平台； 5.指导初级调查人员进行人体受试者研究。 为了实现这些目标，核心将由在艾滋病毒相关方面具有广泛经验的教员指导 研究以及临床研究中的方法论专长。此外，核心将作为连接到 加州大学旧金山分校用于人类主题研究的相关机构资源，包括艾滋病中心的资源 预防研究、生物统计学和临床研究培训计划。通过实现 作为其服务的规模经济，核心将提供资源高效、灵活和及时的支持，以 CFAR成员在以人类为对象的艾滋病毒/艾滋病研究中寻求新的机会。

A primary focus of the UCSF-GIVI CFAR is HIV-related research that is both translational and multidisciplinary. The research often includes studies in which human subjects are the unit of observation and in whom complex biologic, behavioral, and clinical parameters are measured, often in a longitudinal manner. A prerequisite of human subjects research is the direct interaction with and exemplary characterization of both diseased and non-diseased research subjects. As such, the overall objective of the Clinical and Population Sciences Core will be to integrate the population sciences of epidemiology and biostatistics with the clinical science of HIV medicine to facilitate the interaction with and characterization of human subjects as well the analysis of the data and biological specimens derived from them. Fulfilling this objective in turn promotes multidisciplinary collaboration between laboratory-based and human subjectsbased researchers and is the sine qua non of translational research. Accordingly, the specific aims of the Core will be to support innovative human subjects-based HIV-related research by: 1. Providing expertise in the Clinical and Population Sciences related to HIV/AIDS research via consultation regarding conception of research questions, study design, data management, biostatistical analysis, and interpretation of data; 2. Serving as the resource clearinghouse for CFAR investigators who seek to perform new analyses with available data in the many large San Francisco-based and national studies of HIV-infected and at-risk individuals; 3. Managing a unique prospective observational cohort of HIV-infected adults in the contemporary era that provides translational researchers with a diverse array of biological specimens from subjects who are well-characterized in terms of clinical, behavioral, and epidemiologic parameters; 4. Providing a platform for the efficient conduct of newly designed prospective human subjects studies; 5. Mentoring junior investigators in the conduct of human subjects research. To achieve these aims, the Core will be directed by faculty with a wide range of experience in HIV-related research as well as methodological expertise in clinical research. In addition, the Core will serve as a link to related institutional resources at UCSF for human subjects research, including those in the Center for AIDS Prevention Studies, the Division of Biostatistics, and the Training in Clinical Research program. By achieving an economy of scale in its services, the Core will provide resource-efficient, flexible, and timely support to CFAR members as they pursue emerging opportunities in human subjects-based HIV/AIDS research.