Basic Mechanisms in Aging and Age Related Disease

描述(由申请人提供)：巴克年龄研究所是美国唯一一个独立的机构，专门致力于衰老生物学和与年龄相关的疾病的基础研究。它对老龄化研究的密集、跨学科、全机构范围的方法代表了一种新的模式，不同于传统的基于大学的方法，在传统的大学方法中，衰老研究是众多学科之一，分布在整个机构，并与其他学科竞争稀缺的科学资源。在巴克研究所开始运作的五年里，它在老龄化研究方面投入了大量资金并做出了承诺。在这一过程中，巴克研究所的研究人员对衰老生物学和与年龄相关的疾病的研究做出了重要贡献，包括阿尔茨海默氏症、帕金森氏病、中风和癌症，该研究所已确立了自己作为主要老龄化研究中心的地位。我们相信，巴克研究所非常适合实现内森老龄基础生物学卓越中心计划的目标--提高在老龄基础研究方面拥有完善研究计划的机构利用尖端研究资源的能力，并通过以下方式为老龄研究提供最好的环境：(A)提高老龄基础生物学研究的质量；(B)促进老龄研究活动的规划和协调；(C)为新接触老龄研究的研究人员提供支持和合适的环境；以及(D)开发潜在的地区或国家资源中心。为了实现这些目标，我们提议在巴克研究所建立一个休克中心，核心包括以下核心：提供动物护理和程序以及转基因/基因敲除生产的动物/转基因核心；成像核心，其中现有的形态资源将与功能成像技术相补充；基因组核心，将生产cDNA和寡核苷酸微阵列芯片并提供微阵列分析服务；以及蛋白质组学核心，使用质谱仪和新的化学方法来确定与衰老和年龄相关疾病相关的翻译后修饰和蛋白质-蛋白质相互作用网络。最后，研究开发核心将通过博士后培训计划、研究开发研究研讨会、向初级研究人员和新进入老龄领域的研究人员颁发试点项目奖，以及为来自代表性不足的少数族裔背景的高中生和大学生设立暑期学者计划，促进老龄研究人员和项目的发展。

DESCRIPTION (provided by applicant): The Buck Institute for Age Research is the only free-standing institute in the United States that is devoted exclusively to basic research on the biology of aging and age-related diseases. Its intensive, interdisciplinary, institution-wide approach to aging research represents a new model, distinct from the traditional university-based approach in which the study of aging is one of numerous disciplines, spread throughout an institution, and competing with other disciplines for scarce scientific resources. In the five years since the Buck Institute began operation, it has made a substantial investment in and commitment to aging research. In the process, Buck Institute investigators have made important contributions to research on the biology of aging and age-related diseases, including Alzheimer's disease, Parkinson's disease, stroke and cancer, and the Institute has established itself as a major aging research center. We believe that the Buck Institute is ideally suited to fulfill the goal of the Nathan Shock Centers of Excellence in Basic Biology of Aging program - to enhance the ability of institutions with well-developed research programs in basic research on aging to utilize state-of-the-art research resources and provide the strongest environment for the conduct of research on aging by: (a) enhancing the quality of research in the basic biology of aging (b) facilitating the planning and coordination of aging research activities (c) providing support and a suitable environment for investigators new to aging research and (d) developing potential regional or national resource centers. To achieve these objectives, we propose to establish a Shock Center at the Buck Institute with the following Cores: An Animal/Transgenics Core offering animal care and procedures and transgenic/knockout production, an Imaging Core in which existing morphology resources will be supplemented with functional imaging technology, a Genomics Core that will produce cDNA and oligo microarray chips and offer microarray analysis services, and a Proteomics Core using mass spectrometry and new chemical methods to identify posttranslational modifications and protein-protein interaction networks associated with aging and age-related diseases. Finally, a Research Development Core will foster the development of investigators and projects in aging research through postdoctoral training programs, Research Development Research Seminars, Pilot Project awards to junior investigators and investigators new to the aging field, and a Summer Scholars program for high school and college students from underrepresented minority backgrounds.