OPTICAL IMAGING CORE

核心B将作为该计划项目的光学成像和小动物成像核心。詹姆斯博士 莱克莱特是核心领导者，将负责以下工作：1)提供光学显微镜 为方案项目的所有主要调查员提供仪器，特别是接触共焦， 多光子和整体动物成像，2)协调每个项目的努力，以纳入新的 体内光学成像、Micro-SPECT、Micro-PET和Micro-CT等技术用于监测代谢， 衰老过程中DNA增殖和细胞凋亡与解剖成像的相关性，3)提供咨询 并向方案参与者提供关于光学成像理论和应用的教育 确保项目和核心进行的研究的质量的项目；4)提供计算机硬件 以及用于分析数字图像和制作出版质量印刷品的软件。核心B将采取 核心光学成像设施和新闻部已经投入使用的仪器的优势。的 UTHSCSA的放射学。通过每个组织、计划中公认的专家协调工作 项目成员将可以使用最先进的光学和小动物成像仪器 从而使他们能够实施新的方法来研究活细胞、组织和整体的衰老 动物模型。

Core B will serve as the Optical Imaging and Small Animal Imaging core of the Program Project. Dr. James Lechleiter is the core leader and will be responsible for the following: 1) providing optical microscope instrumentation for all of the principle investigators of the program project, in particular access to confocal, multiphoton and whole animal imaging, 2) coordinating efforts of each project to incorporate novel techniques such as in vivo optical imaging, Micro-SPECT, Micro-PET and Micro-CT to monitor metabolism, DNA proliferation, and apoptosis with anatomic imaging correlation during aging, 3) providing consultation and education regarding the theory and application of optical imaging to the participants of the program project to insure the quality of research conducted by the projects and cores, 4) providing computer hardware and software for analysis of digital images and production of publication quality prints. Core B will take advantage of the instrumentation already in operation in the Core Optical Imaging Facility and the Dept. of Radiology at UTHSCSA. By coordinating efforts through recognized experts in each organization, Program Project members will have access to state-of-the-art instrumentation for optical and small animal imaging thus enabling them to implement novel methodologies for the study of aging in living cells, tissues and whole animal models.