Digestive Health Center: Bench to Bedside Research in Pediatric Digestive Disease

总体描述(由申请人提供)： 我们的消化健康中心(DHC)的总体目标是：儿童消化疾病的床到床研究，旨在促进研究，深入了解儿童消化疾病的基本过程和致病机制，并产生创新的治疗方法，以恢复消化健康。我们DHC的目标是促进研究和促进部门间和部门间的合作，以实现更大的消化系统疾病研究的临界量，并专注于翻译研究机会。具体地说，我们的长期目标是通过对我们四个主要目标领域和疾病的更好诊断、治疗和结果来改善儿童健康，这些疾病包括慢性肝病、消化器官(肝脏和肠道)衰竭和移植、炎症性和腹泻性疾病以及肥胖。每个重点领域都代表着对儿童消化健康潜在影响的一个重要领域，提供了推进国家研究议程的机会，代表了辛辛那提儿童医院医学中心和辛辛那提大学医学院的巨大力量和资源投资领域，并提供了将研究整合到患者护理中的直接机会。重点领域由三个高度创新的生物医学研究核心联系在一起，这三个核心是基因表达和测序、生物信息学和综合形态学，以及行政核心的一个临床组成部分，以促进以患者为基础的研究。它们共同构成了一个强大的基础设施，促进了基于这些复杂的G1疾病的遗传学的个性化和预测性医疗方法的开发，以及考虑到疾病基本机制的治疗方法的开发。此外，针对这些关键的重点领域和重要的消化疾病，都有临床和研究小组。我们的方法是在整个研究过程中支持基于疾病的研究；在我们的工作模式中，实验室发现产生转译研究机会，从而导致更明确的以患者为导向的研究，如临床试验。除了促进对儿科消化疾病的了解，我们的DHC的目标还包括招募资深研究人员来研究我们的四个重点领域，加强DHC研究人员之间的合作，并鼓励致力于儿科消化疾病研究事业的年轻研究人员的发展。这些目标是通过试点/可行性奖以及丰富的研讨会、讲习班和专题讨论会计划来实现的。我们作为一个“微型中心”的成功，显著扩大了研究基础，加强了新的合作，发展了我们独特的重点，并通过使用生物医学研究核心为儿科消化系统疾病的前沿研究做出了贡献，并获得了强有力的机构支持，这有力地预示着我们作为一个全面的DDRCC将取得更大的进步。

DESCRIPTION, OVERALL (provided by applicant): The overall goal of our Digestive Health Center (DHC): Bench-to-Bedside Research in Pediatric Digestive Disease is to promote research that will yield insights into the fundamental processes and pathogenic mechanisms of digestive disease in children and generate innovative treatment to restore digestive health. The aims of our DHC are to foster research and promote interdivisional and interdepartmental collaboration to achieve an even greater critical mass in digestive disease research and to focus on translational research opportunities. Specifically, our long term goals are to improve child health through better diagnosis, treatments and outcomes for our four key targeted focus areas and diseases including Chronic Liver Disease, Digestive Organ (Liver and Intestinal) Failure and Transplantation, Inflammatory and Diarrheal Diseases, and Obesity. Each focus area represents an important area of potential impact on digestive health for children, provides an opportunity to advance the national research agenda, represents an area of tremendous strength and resource investment at Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, and affords a direct opportunity to integrate research into patient care. The focus areas are linked by three highly innovative Biomedical Research Cores, Gene Expression and Sequencing, Bioinformatics, and Integrative Morphology, and by a Clinical Component of the Administrative Core to facilitate patient-based research. Collectively they form a powerful infrastructure that fosters the development of personalized and predictive medical approaches based on the genetics of these complex Gl diseases, and of therapies that take into account basic mechanisms of disease. Moreover, clinical and research teams are in place for each of these key focus areas and important digestive diseases. Our approach is to support disease based research across the continuum of research; in our working model, laboratory discoveries generate translational research opportunities that lead to more definitive patient oriented studies such as clinical trials. In addition to advancing the understanding of pediatric digestive disease, the goals of our DHC include the recruitment of established investigators to the study of our four focus areas, enhancing collaboration among DHC investigators and encouraging the development of young investigators committed to pursuing research careers in pediatric digestive disease. These goals are fostered by Pilot/Feasibility awards as well as an enrichment program of seminars, workshops and symposia. Our success as a "minicenter" in significantly enlarging the Research Base, enhancing new collaborations, developing our unique focus and contributing to cutting edge research in pediatric digestive disease by the use of the Biomedical Research Cores and obtaining strong institutional support is strongly predictive of our even greater progress as a full DDRCC.