CORE--ENVIRONMENT /GENE INTERACTIONS

描述（由申请人提供）：该核心于1994年创建，名称为“环境化学品的生物转化和毒性”。2000年4月，该研究所更名为环境-基因相互作用研究所，以反映其向新领域的扩展以及任命Suzie Chen博士为所长。P.托马斯博士继续担任核心小组的共同主任。核心包括来自罗格斯大学6个不同部门和RWJMS 6个部门的16名研究人员。这组调查人员的集体资金为1280万美元。这一数字包括同行审查赠款、合同和合作协议。核心成员福尔斯的研究兴趣包括以下十个研究和合作领域：1）化学预防活性和其他膳食化合物; 2）外源性代谢酶的调控; 3）代谢酶Lambert的遗传多态性; 4）环境样品中植物雌激素的检测; 5）皮肤癌发生中的P53突变; 6）食管癌小鼠模型; 7）恶性黑素瘤的小鼠模型; 8）基因组稳定性; 9）诱变和环境致癌作用;和10）动物模型。其核心目标是：1）鉴定和研究参与细胞对环境暴露反应的基因; 2）表征宿主对环境因子反应导致的基因表达的改变; 3）鉴定与环境反应基因相关的重要遗传多态性; 4）阐明从酵母到哺乳动物的各种模型系统中功能重要的环境反应基因。核心的未来计划包括加强基因组和蛋白质组学方法的使用，开发和增加核心内相互作用，并将动物模型的研究扩展到人类。

Description (provided by applicant): This core was created in 1994 under the name "Biotransformation and Toxicity of Environmental Chemicals." The name was changed to Environment-Gene Interactions in April 2000, reflecting the expansion into new areas and the appointment of Dr. Suzie Chen as the Director. Dr. P. Thomas remains in the leadership of the Core as Co-Director. The core includes 16 investigators from 6 different departments at Rutgers University and 6 departments at RWJMS. The collective funding for this group of investigators is 12.8 million dollars. This number includes peer review grants, contracts, and cooperative agreements. The research interest of the core members falls into the following ten areas of research and collaboration: 1) chemopreventive activities and other dietary compounds; 2) regulation of xenobioticmetabolizing enzymes; 3) genetic polymorphisms of metabolizing enzymes Lambert; 4) detection of phytoestrogens from environmental samples; 5) P53 mutations in skin carcinogenesis; 6) mouse model for esophageal carcinoma; 7) mouse model of malignant melanoma; 8) genomic stability; 9) mutagenesis and environmental carcinogenesis; and 10) animal models. The core goals are, 1) to identify and study genes involved in cellular response to environmental exposure; 2) to characterize the alterations of the gene expression resulting from host responses to environmental factors; 3) to identify important genetic polymorphisms associated with environmental response genes; and 4) to elucidate functionally important environmental response genes in a variety of model systems, from yeast to mammals. The future plans for the core include enhancement of use of genomic and proteomic approaches, develop and increase intracore interaction and to extend studies in animal models to humans.