CORE - ADMINISTRATIVE

自1985年以来，伯克博士一直是我们核心赠款的首席研究员。她曾执导过细胞培养 自1982年她到达本机构以来的模块和指定之前和之后的形态设施 1992年成为核心模块。(形态模块的领导由林克博士在本预算周期内担任。) 伯克博士是研究生教员，她以研究生的身份指导研究生和 博士后研究员，并为医学和研究生教学项目做出贡献。她也在教书 美国国立卫生研究院支持的K30临床研究学者计划，其目标是帮助初级教师 成为成功的临床和/或翻译研究人员。 除了NEI资助的实验室研究外，伯克博士还与 视网膜科的临床教员。她和她的实验室成员每月与临床医生和其他视网膜医生会面 研究人员讨论共同感兴趣的研究问题。 由于伯克博士的工作是多学科的，她是大多数核心模块的主要用户。《细胞》 培养模块维持着几种类型的眼和非眼细胞，这为HER提供了生物材料 学习。为她的研究进行的许多分析都利用了分子生物学中可用的仪器- 生物化学模块和大多数研究也有需要服务或设备的形态成分 形态学舱。此外，她的一些工作是使用转基因小鼠模型进行的，该模型 需要使用动物资源模块。她是图像分析模块的广泛用户，因为 她对共焦成像的需求，以及作为我们活细胞成像系统的主要用户。 伯克博士在1992年至1997年期间担任阿尔沃公司的执行副总裁。在这一身份下，她在 ARVO董事会并担任ARVO方案委员会主席，该委员会负责摘要审查 和组织ARVO年度会议的科学计划。这次经历使她充分了解了 视野研究的广度，使她同情在她所在领域之外工作的科学家的需求 接受修改核心模块以确保它们继续满足尽可能多的调查人员的需求 尽可能的。

Dr. Burke has been principal investigator on our Core Grant since 1985. She has directed the Cell Culture Module since her arrival at this institution in 1982 and the morphology facility both prior to and after its designation as a Core Module in 1992. (Morphology Module leadership was assumed by Dr. Link during this budget cycle.) Dr. Burke is a member of the graduate faculty and in that capacity she mentors graduate students and postdoctoral fellows and contributes to medical and graduate teaching programs. She is also on the teaching faculty of an NIH-supported K30 Clinical Research Scholars Program which has a goal of helping junior faculty become successful clinical and/or translational researchers. In addition to laboratory studies funded by the NEI, Dr. Burke has collaborated for several years with the clinical faculty in the retina section. She and members of her lab meet monthly with the clinicians and other retina researchers to discuss research questions of common interest. Since Dr. Burke's work is multidisciplinary, she is a major user of most of the Core modules. The Cell Culture Module maintains several types of ocular and nonocular cells, which provide the biological material for her studies. Many assays performed for her research make use of instrumentation available in the Molecular Biology- Biochemistry Module and most studies also have a morphologic component requiring the services or equipment in the Morphology Module. Additionally, some of her work is conducted using a transgenic mouse model, which requires use of the Animal Resource Module. She is an extensive user of the Image Analysis Module by virtue of her need for confocal imaging and as the primary user of our live cell imaging system. Dr. Burke served as Executive Vice President of ARVO from 1992 to 1997. In that capacity, she served on the ARVO Board of Trustees and chaired the ARVO Program Committee, which is responsible for abstract review and organization of the scientific program for the ARVO Annual Meeting. This experience exposed her to the full breadth of vision research, making her sympathetic to the needs of scientists working outside her area and receptive to modifying the Core Modules to assure that they continue to meet the needs of as many investigators as possible.