2008 Calcium Signaling and Disease SGP Conference

描述（由申请人提供）：本申请申请资金用于支持将于2008年9月3日至7日在马萨诸塞州伍兹霍尔海洋生物实验室举行的“钙信号与疾病”国际研讨会。本次会议将是第62届普通生理学家协会（SGP）年会。SGP的主要目的是每年举办一次研讨会，讨论细胞生物学家、生理学家和生物物理学家广泛感兴趣的不同主题。为2008年会议选择的主题尤其及时和引人注目。之前的SGP会议（1986年和1998年）集中在会议召开时的前沿Ca2+信号研究。在筹备2008年会议的过程中，很明显，最近Ca2+信号领域的爆炸性发展首次将重点放在了疾病导向的研究上。虽然许多Ca2+信号会议纳入了“疾病”会议，但我们的研讨会将是美国第一个专门关注Ca2+信号病理方面的研讨会。在选择我们的项目时，我们专注于几个关键的研究领域，这些领域的进展最引人注目，获得的线索最诱人。这些领域是：(1)心脏和骨骼肌疾病（心律失常、猝死综合征、恶性高热和肌肉萎缩症），(2)神经退行性疾病（阿尔茨海默氏症、亨廷顿氏症和帕金森症）；(3)中枢神经系统疾病（家族性偏头痛、自闭症）；(4)与Ca2+泵功能障碍相关的疾病（耳聋、Darier病和Hailey-Hailey病）；(5)与TRP通道家族功能障碍相关的疾病（多囊肾病、低镁血症、不孕症和糖尿病）。这些主题代表了跨越几个医学亚专业的疾病相关项目的独特融合，但统一的是他们对Ca2+信号的关注。我们预计这次会议将吸引大量从事Ca2+信号研究的科学家，但也有一些临床科学家和疾病导向的基础研究人员，他们以前没有接触过最前沿的Ca2+信号研究。我们希望通过促进传统“Ca2+信号研究人员”和“疾病研究人员”之间的交流，我们的会议将在加速该领域的进展及其转化为临床见解和实践方面发挥重要作用。由普通生理学家协会组织的会议似乎为促进转化生物医学研究的关键发展做好了理想的准备。公共卫生相关性：本提案请求资金支持将于2008年9月3日至7日在马萨诸塞州伍兹霍尔海洋生物实验室举行的“钙信号与疾病”国际研讨会。本次会议将是第62届普通生理学家协会（SGP）年会。SGP的主要目的是每年举办一次研讨会，讨论细胞生物学家、生理学家和生物物理学家广泛感兴趣的不同主题。

DESCRIPTION (provided by applicant): This proposal requests funds to help support an international symposium on "Calcium signaling and disease" to be held September 3 - 7, 2008, at the Marine Biological Laboratory in Woods Hole, Massachusetts. This meeting will be the 62nd Annual Symposium of the Society of General Physiologists (SGP). The major purpose of the SGP is to host a symposium each year on a different subject of wide interest to cell biologists, physiologists and biophysicists. The topic chosen for the 2008 meeting is especially timely and compelling. The previous SGP meetings (in 1986 and 1998) were focused on the cutting-edge Ca2+ signaling research at the time when those meetings were held. In planning the 2008 meeting, it became clear that recent explosive developments in the area of Ca2+ signaling for the first time actually placed a focus on disease-oriented research within reach. Although many Ca2+ signaling meetings incorporated a "disease" session, our symposium will be the first in the U.S. focused exclusively on pathological aspects of Ca2+ signaling. In selecting our program we focused on several key areas of research where the progress has been most dramatic, and the obtained clues most tantalizing. These areas are: (1) cardiac and skeletal muscle diseases (arrhythmia, sudden death syndrome, malignant hyperthermia and muscular dystrophy), (2) neurodegenerative disease (Alzheimer's, Huntington's, and Parkinson's); (3) disorders of the central nervous system (familial migraine and autism); (4) disorders linked to dysfunction of Ca2+ pumps (deafness, Darier and Hailey-Hailey disease); (5) disorders linked to dysfunction of the trp channel family (polycystic kidney disease, hypomagnesaemia, infertility and diabetes). These topics represent a unique blend of disease-related projects spanning several medical subspecialties but unified by their focus on Ca2+ signaling. We expect that this conference will attract a significant number of scientists working on Ca2+ signaling but also a number of clinical scientists and disease- oriented basic researchers who have not been exposed to cutting edge Ca2+ signaling research previously. We hope that by promoting an exchange between traditional "Ca2+ signaling researchers" and "disease researchers" our meeting will play an important role in accelerating progress in the field and its translation into clinical insights and practice. The meetings organized by the Society of General Physiologists seem to be ideally poised to facilitate such critical developments in translational biomedical research. PUBLIC HEALTH RELEVANCE: This proposal requests funds to help support an international symposium on "Calcium signaling and disease" to be held September 3 - 7, 2008, at the Marine Biological Laboratory in Woods Hole, Massachusetts. This meeting will be the 62nd Annual Symposium of the Society of General Physiologists (SGP). The major purpose of the SGP is to host a symposium each year on a different subject of wide interest to cell biologists, physiologists and biophysicists.