2008 Cardiac Regulatory Mechanisms Gordon Research Conference

描述(由申请人提供)： 本申请寻求为将于2008年7月20-25日在科尔比-索耶学院(科尔比-索耶，NH)举行的“心脏调节机制”戈登研究会议(GRC)提供部分资金。年轻的研究人员和老牌领导人将介绍最新的未发表调查结果，讨论领导人将推动热烈的讨论和批判性提问。演讲的主题包括心脏信号、干细胞和再生、亚细胞钙的分子控制、转录调控和线粒体信号动力学。此外，还会出现肌丝行为和信号功能障碍，以及性别和年龄的影响。杰出的发言者是从过去两年没有在本次会议上发言的人中挑选出来的。这次会议旨在促进所有与会者之间的讨论和互动，符合GRC的传统和这次特别会议25年的历史。参与者将从来自不同学科、在其职业生涯的所有阶段都有才华和多产的科学家中挑选出来，他们都对正常和患病心脏的调节这一主题有共同的兴趣。这次会议的一个主要目标是营造一种包容、热烈、活跃和互动的氛围，创造富有成效的讨论，并使新想法得以交流，鼓励每个人都参与其中。GRC的特殊非正式性质促进了跨越学科和地理的讨论，并使新的个人和科学联系得以发展。GRC也是年轻和成熟的调查人员进行有意义的互动的地方。这是心血管科学中一个令人兴奋的时期，因为新技术的出现使我们能够探索正常心脏功能的细胞和分子基础。我们正开始将这些新发现转化为对疾病机制、诊断、预防和治疗的更好理解。我们已经有了很好的基础科学，涉及正常心脏电和机械特性的调节，心肌细胞信号传递，以及这些过程中导致心功能障碍的异常。拟议的发言(见下文)可能既令人兴奋又及时。最新的科学将慷慨地参加口头会议，发言者从海报稿件和最近的出版物中招募。(摘要结束)

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research Conference (GRC) on "Cardiac Regulatory Mechanisms" to be held at Colby Sawyer College (Colby-Sawyer, NH) on July 20-25, 2008. Young investigators and established leaders will present the latest unpublished findings and the discussion leaders will promote lively discussions and critical questioning. The topics presented will include cardiac signaling, stem cells and regeneration, molecular control of subcellular Ca2+, transcriptional modulation and mitochondrial signaling dynamics. In addition, myofilament behavior and signaling dysfunction will be presented as will influence of gender and aging. Outstanding speakers have been chosen from those who have not presented at this meeting in the last two years. The meeting seeks to foster discussion and interaction among all participants, consistent with GRC tradition and the 25-year history of this particular conference. Participants will be chosen from the talented and productive scientists at all stages in their careers from diverse disciplines, all with a common interest in the topic of regulation of the normal and diseased heart. A key objective of this conference is to foster an inclusive, intense, lively and interactive atmosphere that creates productive discussions and enables exchanges of novel ideas, where everyone is encouraged to participate. The special informal nature of the GRC has promoted discussions that span disciplines and geography and has enabled new personal and scientific connections to develop. The GRC is also a place for young and established investigators to have meaningful interactions. This is an exciting time in cardiovascular science because of the advent of novel technologies that allow us to explore the cellular and molecular bases of normal cardiac function. We are beginning to translate these new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. We have had a good mix of fundamental science related to regulation of normal cardiac electrical and mechanical properties, cardiac myocyte cell signaling, and abnormalities in these processes that contribute to cardiac dysfunction. The proposed presentations (see below) are likely to be both exciting and timely. Late breaking science will be generously represented in the oral session with speaker recruited from poster contributions and recent publications. (End of Abstract)