Effect of Medicinal Plants used by Tribes on Cancer and Bacteria

描述(申请人提供)：这项拟议工作的最终目标是寻找新的自然产生的抗癌和抗细菌活性成分。癌症是美国的主要死亡原因之一，占每年死亡人数的22%。新的潜在抗癌药物及其作用机制的发现将使癌症的治疗取得重大进展。在过去的十年里，由于迫切需要确定对具有高耐药性的病原体具有活性的新物质，人们对使用天然产品作为潜在的抗菌剂来源的兴趣有所增加。药用植物的重要作用在生化和生物医学界以及制药业中得到了广泛的认可。然而，有关药用植物中生物活性成分的科学知识仍处于早期阶段。几个世纪以来，美洲原住民部落一直使用药用植物来治疗各种疾病。新墨西哥州的美洲原住民目前特别使用两种植物来治疗包括癌症在内的各种疾病：门叶女贞(Ligusticum Porteri)和加州银莲花(Anemopsis California)。关于波特兰和加利福尼亚州海葵的重要研究极其有限。本申请中提出的工作集中在i)筛选可能的抗癌和抗细菌生物活性成分；ii)它们的结构确定。索氏提取物、细胞毒性试验、生物活性筛选、层析分离、核磁共振和质谱学等技术将被用于科学地探索这些药用植物的抗癌和抗菌成分。在过去的十年里，由于迫切需要确定对癌症和病原体具有高耐药性的新物质，人们对使用天然产品作为抗癌和抗菌剂的潜在来源的兴趣有所增加。加州黄曲霉和门冬青的生物活性成分有望作为抗癌和/或抗菌药物。与公共卫生相关：过去十年，由于迫切需要确定对癌症和病原体具有高耐药性的新物质，人们对使用天然产品作为抗癌和抗菌剂的潜在来源的兴趣有所增加。加州红曲霉和波特里红曲霉的生物活性成分有望成为抗癌和/或抗菌药物。

DESCRIPTION (provided by applicant): The ultimate goal of this proposed work is to find new naturally occurring active components against cancer and bacteria. Cancer is one of the major causes of death in the U.S. and accounts for 22% of all annual deaths. The discovery of new potential anti-cancer drugs and their mechanism of action can lead to significant progress in the treatment of cancer. Interest in the use of natural products as potential sources of antibacterial agents has increased over the last decade due to an urgent need to identify novel substances active towards pathogens with high resistance. The critical role of medicinal plants is being widely recognized in the biochemical and biomedical world as well as in the pharmaceutical industry. However, scientific knowledge concerning biologically active components in medicinal plants is still in its early stages. For centuries, Native American tribes have used medicinal plants to treat a broad range of diseases. Two plants in particular are currently being used by Native Americans in New Mexico, to treat various types of diseases, including cancer: Ligusticum porteri (Osha), and Anemopsis California (Yerba Manza). Significant research regarding Ligusticum porteri and Anemopsis California is extremely limited. The work proposed in this application focuses on I) screening for possible biologically active components against cancer and bacteria; ii) their structure determination. Soxhlet extractions, cytotoxicity tests, biological activity screening, chromatographic separations, NMR and Mass spectrometry, are techniques that will be utilized to scientifically explore these medicinal plants for anticancer and antibacterial components. Narrative Interest in the use of natural products as potential sources of anticancer and antibacterial agents has increased over the last decade due to an urgent need to identify novel substances active towards cancer and pathogens with high resistance. Biological active components of A. California and L. Porteri might be promising as anticancer and/or antitibiotic agents. PUBLIC HEALTH RELEVANCE: Interest in the use of natural products as potential sources of anticancer and antibacterial agents has increased over the last decade due to an urgent need to identify novel substances active towards cancer and pathogens with high resistance. Biological active components of A. Californica and L. Porteri might be promising as anticancer and/or antitibiotic agents.