2008 Mechanisms of Epilepsy and Neuronal Synchronization GRC

描述（由申请人提供）：我们请求NINDS支持将于2008年8月3日至8日在缅因州的科尔比学院举行的关于癫痫和神经元同步机制的戈登研究会议。癫痫发作研究的主要目标是确定神经元网络中同步放电的潜在机制，以便开发更有效和毒性更小的癫痫治疗和治愈方法。癫痫研究的一个独特的、智力上具有挑战性的方面来自于这样一个事实，即它几乎涵盖了生物组织的所有主要水平，从基因和离子通道到电路和行为。这次戈登会议的主要目的是汇集遗传学家，分子生物学家，发育神经科学家，神经解剖学家，电生理学家和计算神经科学家，他们致力于直接或间接与癫痫发作相关的基本机制，以综合当前的进展并为未来的发现奠定基础。本次会议的主题是可塑性和癫痫，涉及的主题包括：癫痫的发育可塑性/起搏，癫痫的转化治疗方法，癫痫中的受体可塑性，癫痫中的离子通道可塑性，癫痫中神经元的出生、迁移和死亡，可塑性对网络行为的后果，发育和癫痫中同步网络行为的机制，和癫痫/兴奋性中的受体运输。我们的目标是传播最新的科学进展，促进富有成效的新见解和合作，并为新的转化研究奠定基础，以便在最短的时间内将最新的发现带到床边。公共卫生相关性：癫痫是一种慢性疾病，影响全球5000万人。开发新的治疗策略，以更好地治疗和潜在地治愈这种毁灭性的疾病，需要科学的进步，以更好地了解癫痫的分子和细胞机制。本次会议将汇集来自世界各地的专家在一个密集的，身临其境的环境，介绍和讨论新的发现，促进知识的传播和催生合作。这将极大地推动针对更好地治疗癫痫的研究。

DESCRIPTION (provided by applicant): We are requesting NINDS support for a Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization to be held August 3-8, 2008 at Colby College in Maine. The main goal of the study of seizures is to identify the mechanisms underlying synchronous electrical discharges in neuronal networks in order to develop more effective and less toxic treatments and cures for epilepsy. A unique, intellectually challenging aspect of epilepsy research arises from the fact that it encompasses virtually all major levels of biological organization, from genes and ion channels to circuits and behavior. The major purpose of this Gordon conference is to bring together geneticists, molecular biologists, developmental neuroscientists, neuroanatomists, electrophysiologists, and computational neuroscientists working on basic mechanisms related either directly or indirectly to seizure generation to synthesize current advances and set the stage for future discoveries. The theme of the current conference is Plasticity and Epilepsy, and topics to be covered include: Developmental plasticity/pacemaking in epilepsy, Translational therapeutic approaches in epilepsy, Receptor plasticity in epilepsy, Ion channel plasticity in epilepsy, birth, migration, and death of neurons in epilepsy, Consequences of plasticity on network behavior, Mechanisms of synchronous network behavior in development and epilepsy, and Receptor trafficking in epilepsy/excitability. Our goals are to disseminate the latest scientific advances, foster productive new insights and collaborations, and set the stage for new translational studies that will bring the newest discoveries to the bedside in the shortest possible time. PUBLIC HEALTH RELEVANCE: Epilepsy is a chronic condition that affects 50 million people worldwide. Development of novel therapeutic strategies to better treat and potentially cure this devastating condition requires scientific advances to better understand the molecular and cellular mechanisms responsible for epilepsy. This conference will bring together experts from all over the world in an intensive, immersive environment to present and discuss novel findings, facilitating dissemination of knowledge and spawning collaborations. This should significantly advance research directed towards better treatment of epilepsy.