2008 Ion Channels Gordon Research Conference

描述(由申请者提供)：本提案请求部分支持将于2008年7月6-11日在新罕布夏州蒂尔顿的蒂尔顿学校举行的戈登研究会议系列的一部分，关于离子通道的国际会议。会议的广泛和长期目标是增加我们对离子通道的基本结构、功能和生理作用以及它们在疾病中的功能障碍的理解，特别是在神经系统疾病中。这次会议的具体目标是召集代表离子通道研究关键领域的44位演讲者和讨论领导人，总共135名与会者，在一个相对隐蔽的环境中举行为期五天的会议。该计划将有九个会议，广泛讨论当前离子通道调节、生物物理学、结构、生理作用和疾病中的功能障碍等问题。此外，四人会议将允许所有参与者为这些主题贡献他们的工作。这项申请的意义在于，离子通道戈登研究会议是国际离子通道生物学家社区中培养思想和研究的既定会议的关键组成部分。事实上，离子通道GRC所产生的小范围和密集的讨论使其对于在参与者中催化新的想法和方向具有独特的重要性。这一应用程序与健康相关的是，讨论将确定需要在影响人类发展和健康的广泛领域进行实验解决的问题。与公共健康相关：这项应用的相关性在于，对尖端研究的详细讨论将确定在影响人类发育的领域需要通过实验解决的问题，以及几乎所有组织和器官系统的兴奋性障碍，包括中枢神经系统、感官器官、胰腺、心脏、平滑和骨骼肌。这些问题也将与人类老龄化直接相关。最终，这些问题的定义和实验解决将为各种人类疾病的创新治疗方法铺平道路。

DESCRIPTION (provided by applicant): This proposal requests partial support for an internationally attended meeting on Ion Channels, as part of the Gordon Research Conference series, to be held at the Tilton School in Tilton, New Hampshire, July 6-11, 2008. The broad and long-term goal of the conference is to increase our understanding of the fundamental structure, function and physiological roles of ion channels as well as their dysfunction in disease, particularly neurological disorders. The specific aims of this meeting will be to convene 44 speakers and discussion leaders that represent critical areas of ion channel research with a total of 135 participants for a five-day meeting in a relatively secluded setting. The program will have nine sessions that broadly address current issues in ion channel regulation, biophysics, structure, physiological roles and dysfunction in disease. In addition, four poster sessions will permit all participants to contribute their work to these topics. The significance of this application is that the Ion Channels Gordon Research Conference is a critical component of the established meetings that fertilize ideas and research in the international community of ion channel biologists. Indeed, the small size and intensive discussions engendered by the Ion Channels GRC make it uniquely important for the catalysis of new ideas and directions among the participants. The health relatedness of this application is that the discussions will define questions that require experimental resolution in a wide variety of areas that affect human development and health. PUBLIC HEALTH RELEVANCE: The relevance of this application is that the detailed discussions of cutting edge research will define the questions that require experimental resolution in areas that affect human development, and excitability disorders of almost every tissue and organ system, including the central nervous system, sensory organs, the pancreas, cardiac, smooth and skeletal muscle. These questions will also be directly relevant to human aging. Ultimately, the definition and experimental resolution of these issues will pave the way for innovative therapeutic approaches to a wide variety of human diseases.