Schizophrenia PORT Treatment Recommendations Update 2008

描述（由申请人提供）：大量资源已用于开发治疗建议和其他类型的循证临床指南，用于各种健康状况，包括精神分裂症和其他严重精神疾病。治疗精神分裂症患者的技术，包括新的药物和社会心理治疗，正在迅速发展。为了跟上新的研究成果，治疗建议必须定期更新，以确保提高护理质量的努力反映当前的经验知识。精神分裂症患者结局研究小组（PORT）治疗建议最初发表于1998年，随后于2003年更新。这项R13拨款申请要求两年的资助，用于组织和指导2008年的一次会议，就证据基础达成专家共识，以更新和扩展精神分裂症PORT治疗建议。这笔拨款将用于建立一个基础设施，以审查2002年以来发表的关于精神分裂症治疗的疗效和有效性的新研究成果，这些研究成果将在会议上讨论。该基础设施将包括开发一个基于互联网的工具，用于总结从研究报告中摘录的数据，显示治疗建议草案，获取和总结专家对建议草案的评级和评论，并在会议结束后向公众展示建议的最终版本。2008年PORT更新会议的主要参与者将包括马里兰大学精神病学系的教员，他们将负责审查精神分裂症精神药理学和社会心理治疗的新证据。教师将由一个由科学专家和相关利益相关者组成的咨询委员会指导，他们也将作为一个更大的专家小组的一部分参与。专家小组将对建议草案提供评级和评论，并将在2008年会议上召开会议，就证据基础的解释和建议的最终措辞达成共识。该项目针对NIMH服务和干预研究部服务研究和临床流行病学分部的一个明确重点领域，即开发一个健全的知识基础，以大幅增加对精神障碍的科学治疗和服务的可持续吸收。精神分裂症的患病率、严重程度和费用使这种精神疾病成为一个主要的公共卫生问题。制定了精神分裂症患者结局研究小组（PORT）治疗建议，以帮助确保精神分裂症患者获得当前经验知识支持的最高质量治疗。这项R13会议拨款将支持更新精神分裂症PORT治疗建议的工作，以跟上有关精神分裂症适当和有效治疗的新研究成果。

DESCRIPTION (provided by applicant): Significant resources have been expended in the development of treatment recommendations and other types of evidence-based clinical guidelines for a variety of health conditions, including schizophrenia and other severe mental illnesses. Technologies for treating persons with schizophrenia, including new medications and psychosocial treatments, are rapidly evolving. To keep pace with new research findings, treatment recommendations must be regularly updated to ensure that efforts to improve quality of care reflect current empirical knowledge. The Schizophrenia Patient Outcomes Research Team (PORT) Treatment Recommendations were initially published in 1998 and subsequently updated in 2003. This R13 grant application requests two years of funding to organize and direct a conference in 2008 to develop expert consensus on the evidence base to update and expand the Schizophrenia PORT Treatment Recommendations. This grant will enable the development of an infrastructure to review new research findings published since 2002 on the efficacy and effectiveness of treatments for schizophrenia that will be discussed at the conference. This infrastructure will include the development of an internet-based tool for summarizing data abstracted from research reports, displaying drafts of the treatment recommendations, obtaining and summarizing experts' ratings of and comments on the draft recommendations, and displaying the final version of the recommendations for the general public after the conference. Key participants in the 2008 PORT update conference will include faculty from the University of Maryland Department of Psychiatry who will be responsible for reviewing the new evidence on psychopharmacologic and psychosocial treatments for schizophrenia. The faculty will be guided by an Advisory Board of scientific experts and relevant stakeholders, who will also participate as part of a larger Expert Panel. The Expert Panel will provide ratings and comments on the draft recommendations and will convene at the 2008 conference to reach consensus on the interpretation of the evidence base and the final wording of the recommendations. This project addresses an explicit area of emphasis of the Services Research and Clinical Epidemiology Branch within the NIMH Division of Services and Interventions Research, which is to develop a sound knowledge base to substantially increase the sustainable uptake of scientifically based treatments and services for mental disorders. The prevalence, severity and costs of schizophrenia combine to make this psychiatric illness a major public health concern. The Schizophrenia Patient Outcomes Research Team (PORT) Treatment Recommendations were developed to help ensure that individuals with schizophrenia receive the highest quality treatments supported by current empirical knowledge. This R13 conference grant will support efforts to update the Schizophrenia PORT Treatment Recommendations in order to keep pace with new research findings on appropriate and effective treatments for schizophrenia.