Translational Science

核心I：翻译科学 翻译科学核心成立于2002年。这个核心的目的是为了促进 塔夫茨CFAR调查员开发和实施新的临床/翻译艾滋病毒研究 和布朗以及在国际网站上。核心应对CFAR疫情演变为 更复杂的综合征，需要将基础和临床研究扩展到转化性研究 能够检查基础研究的临床意义并确定基本机制 在临床研究中所作的观察。对核心的资助使跨学科的发展成为可能。 原本不会得到支持的研究，并招募了优秀的新研究人员来启动艾滋病毒 相关研究项目。这一核心提供的服务是多样化的，并导致了 一组多样化的研究。 核心的主要目标是： 1.具体支持调查人类免疫缺陷病毒感染的作用(病毒 病毒感染引起的负担、病毒类型和炎症变化)对临床结局的影响 包括抵抗力的发展，以及代谢和体型变化的发展(艾滋病毒相关 脂肪营养不良)。 2.支持艾滋病毒并发症及其治疗，包括结核病的翻译研究， 腹泻疾病，如隐孢子虫感染和抗逆转录病毒药物毒性。 3.支持翻译研究发展必要的基础设施和专门知识 这些复杂的研究，将根据现场和调查人员的需要进行定义。 演出现场(S)(组织、市、州) 塔夫茨大学，波士顿，马萨诸塞州 小灵通398(04/06版)第377页表格第2页

Core I: Translational Science The Translational Science Core was established in 2002. The intent of this core is to facilitate the development and implementation of novel clinical/translational HIV studies by CFAR investigators at Tufts and Brown as well as at international sites. The core responds to the evolution of the CFAR epidemic into an ever more complex syndrome which requires expansion of basic and clinical research to translational studies that are capable of examining the clinical import of basic research and identifying the basic mechanisms for observations made in clinical studies. Funding of the core has permitted the development of interdisciplinary studies that would not otherwise be supported and has recruited excellent new investigators to initiate HIV related research projects. The services provided by this core are diverse and have led to the development of a diverse group of studies. The primary aims of the core are to: 1. Specifically support the investigation of the role of human immunodeficiency virus infection (viral burden, viral type and inflammatory changes induced by the viral infection) on clinical outcomes including development of resistance, and development of metabolic and body shape changes (HIVassociated lipodystrophy). 2. Support translational studies of complications of HIV and its therapies, including tuberculosis, diarrheal disease such as cryptosporidal infection and antiretroviral drug toxicities. 3. Support of translational studies in developing the infrastructure and expertise necessary to conduct these complex studies, to be defined as needed by the site and the investigator. PERFORMANCE SITE(S) (organization, city, state) Tufts University, Boston, MA PHS 398 (Rev. 04/06) Page 377 Form Page 2