Clinical and Population Sciences

UCSF-GIVI CFAR的主要重点是与艾滋病毒相关的研究， 多学科的。这项研究通常包括以人类为观察单位的研究 在这些人中，复杂的生物学、行为学和临床参数被测量，通常是纵向的， 方式人类主体研究的一个前提是直接的互动和示范 表征患病和非患病的研究对象。因此， 临床和人口科学的核心将是整合流行病学的人口科学， 生物统计学与艾滋病毒医学的临床科学，以促进相互作用和表征 人类受试者以及对数据的分析和从中获得的生物标本。履行这一 目标反过来促进基于实验室和基于人类受试者之间的多学科合作 研究人员和翻译研究的必要条件。因此， 核心将是通过以下方式支持以人类受试者为基础的艾滋病毒相关创新研究： 1.通过咨询提供与艾滋病毒/艾滋病研究有关的临床和人口科学方面的专业知识 关于研究问题的概念、研究设计、数据管理、生物统计分析，以及 数据解释; 2.作为CFAR调查人员的资源交换所，他们寻求使用 在许多大型的旧金山和全国性的艾滋病毒感染者和高危人群的研究中， 个人; 3.管理当代艾滋病毒感染成人的独特前瞻性观察队列， 为翻译研究人员提供了来自受试者的各种生物标本， 在临床、行为和流行病学参数方面得到充分表征; 4.为有效开展新设计的前瞻性人类受试者研究提供平台; 5.指导初级研究人员进行人类受试者研究。 为了实现这些目标，核心将由在艾滋病毒相关领域拥有广泛经验的教师指导 研究以及临床研究的方法学专业知识。此外，核心将作为一个链接， 相关的机构资源在加州大学旧金山分校的人类受试者的研究，包括那些在艾滋病中心 预防研究，生物统计学部门和临床研究计划培训。通过实现 为了实现服务的规模经济，核心小组将提供资源高效、灵活和及时的支持， CFAR成员，因为他们追求新的机会，在人类受试者为基础的艾滋病毒/艾滋病研究。

A primary focus of the UCSF-GIVI CFAR is HIV-related research that is both translational and multidisciplinary. The research often includes studies in which human subjects are the unit of observation and in whom complex biologic, behavioral, and clinical parameters are measured, often in a longitudinal manner. A prerequisite of human subjects research is the direct interaction with and exemplary characterization of both diseased and non-diseased research subjects. As such, the overall objective of the Clinical and Population Sciences Core will be to integrate the population sciences of epidemiology and biostatistics with the clinical science of HIV medicine to facilitate the interaction with and characterization of human subjects as well the analysis of the data and biological specimens derived from them. Fulfilling this objective in turn promotes multidisciplinary collaboration between laboratory-based and human subjectsbased researchers and is the sine qua non of translational research. Accordingly, the specific aims of the Core will be to support innovative human subjects-based HIV-related research by: 1. Providing expertise in the Clinical and Population Sciences related to HIV/AIDS research via consultation regarding conception of research questions, study design, data management, biostatistical analysis, and interpretation of data; 2. Serving as the resource clearinghouse for CFAR investigators who seek to perform new analyses with available data in the many large San Francisco-based and national studies of HIV-infected and at-risk individuals; 3. Managing a unique prospective observational cohort of HIV-infected adults in the contemporary era that provides translational researchers with a diverse array of biological specimens from subjects who are well-characterized in terms of clinical, behavioral, and epidemiologic parameters; 4. Providing a platform for the efficient conduct of newly designed prospective human subjects studies; 5. Mentoring junior investigators in the conduct of human subjects research. To achieve these aims, the Core will be directed by faculty with a wide range of experience in HIV-related research as well as methodological expertise in clinical research. In addition, the Core will serve as a link to related institutional resources at UCSF for human subjects research, including those in the Center for AIDS Prevention Studies, the Division of Biostatistics, and the Training in Clinical Research program. By achieving an economy of scale in its services, the Core will provide resource-efficient, flexible, and timely support to CFAR members as they pursue emerging opportunities in human subjects-based HIV/AIDS research.