LSI Doctoral Training Centres - The doctoral training centre in chemical biology

DTC的研究将专注于了解蛋白质-蛋白质和脂-蛋白质相互作用。对这些大分子相互作用的定量测量和建模，以及能够破坏它们的新分子的合成将开辟全新的治疗疾病的途径，并最终对临床有益。DTC化学生物学旨在利用英国在基因组学中的强大地位，提供一座桥梁，进入DTC博士研究人员开发的新的分子后基因组工具和技术，他们在物理科学/生命科学领域工作。学生既是开发工具和技术的手段，也是将物理科学的量化观点带入重要生物学问题的桥梁。RCUK(http://w，Avw.rcuk.ac.uk/aboutreuk/executivegroup/egmeetings/feb07/070221report.htm)和http://pubs.acs.org/cen/employment/84/8416chemicalbiology.html).Our)强调了对这类研究人员的需求(例如，在与制药部门的高级研究策略师磋商后，选择了特别关注蛋白质-蛋白质和脂-蛋白质相互作用，他们认识到，学习如何干扰这些相互作用将构成治疗疾病的新药物方法的基础。然而，他们也认识到，这种方法将需要在学术界内发展，并将需要多学科的研究人员将这些想法带到他们的身上并进入行业。他们对这项提议的支持反映了这些较长期的意图。

The DTC's research will focus on the understanding of protein-protein and lipid-protein interaction.Quantitative measurement and modelling, of these macromolecular interactions, and the synthesis of new molecules with the ability to disrupt them will open up entirely novel avenues to attack diseases and ultimately be of clinical benefit.The Chemical Biology DTC is designed to exploit the UK's strong position in genomics by providing a bridge into new molecular post-genomic tools and technologies developed by DTC PhD researchers who work at the physical sciences/life sciences interface. The students are both the means by which the tools and technology are developed and the bridge that brings the quantitative perspectives of physical sciences to important biological problems. The need for such researchers has been highlighted by RCUK (http://w,Avw.rcuk.ac.uk/aboutreuk/executivegroup/egmeetings/feb07/070221report.htm) and thepharmaceutical sector (e.g. http://pubs.acs.org/cen/employment/84/8416chemicalbiology.html).Our particular focus on protein-protein and lipid-protein interactions has been chosen following consultation with senior research strategists from the pharmaceutical sector, who recognise that learning how to interfere with these interactions would form the basis for new pharmaceutical approaches to disease. However, they also recognise that such approaches will need to grow within academia and will require multidisciplinary researchers to carry these ideas with them and into industry. Their support of this proposal is a reflection of these longer term intentions.