A behavioral trial for parents of childhood cancer survivors with neurobehavioral

描述(申请人提供)：超过50%的被诊断为癌症的儿童由于中枢神经系统(CNS)疾病和/或中枢神经系统定向治疗(如颅脑放射和鞘内化疗)而面临不良神经认知变化的风险。虽然有大量研究来确定和量化儿童癌症对神经行为的不利影响，但治疗此类后遗症的治疗干预措施的经验研究才刚刚出现。目前提出的这项研究是对癌症生存质量计划公告的回应，代表着推进研究的重要一步，以改善和管理接受中枢神经系统指导治疗的儿童癌症幸存者的神经认知和行为晚期效应。这项研究具有创新性，因为它有别于最近以诊所为基础的以儿童为导向的补救努力，到目前为止，这些努力只产生了有限的和很小的好处，而是探索了一种不同的途径来积极影响儿童结果的潜力。这项研究引导了一项行为试验，以经验性地评估父母干预的影响，主要目的是改善孩子的学习、认知和行为功能。我们已经为我们的父母干预编写了一本培训手册，其中阐述了四个基本的育儿要素，这些要素对于促进孩子的学习和学业成功至关重要。我们将评估实施我们计划的可行性，跟踪遵守情况，并收集有关影响的初步数据。项目相关性：这项研究有望增加对接受中枢神经系统定向治疗的儿童以及有神经认知和行为/适应困难的儿童的具体育儿活动是否可能对学习和学习表现产生积极影响的知识。

DESCRIPTION (provided by applicant): More than 50% of children diagnosed with cancer are at risk for adverse neurocognitive changes due to central nervous system (CNS) disease and/or CNS directed therapy, such as cranial radiation and intrathecal chemotherapy. While there are a large number of studies to identify and quantify the adverse neurobehavioral impact of childhood cancer, empirical investigations of therapeutic interventions to treat such sequelae are only now emerging. The current proposed study, in response to a Program Announcement for quality of cancer survival, represents an important step in advancing the research to improve and manage neurocognitive and behavioral late effects in childhood cancer survivors with CNS-directed therapy. The study is innovative in that it diverges from the recent, child directed remediation efforts based in the clinic, which thus far have yielded limited and only small benefits, and instead explores the potential of a different route to positively influence child outcomes. The study pilots a behavioral trial to empirically evaluate the impact of a parent intervention for the primary purpose of improving the child's academic, cognitive, and behavioral functioning. We have developed a training manual for our parent intervention that addresses four basic parenting components important to promote learning and school success in the child. We will evaluate the feasibility of implementing our program, track adherence, and collect preliminary data on the impact. Project Relevance: This study is expected to increase knowledge about whether specific parenting activities may positively impact learning and school performance in children treated with CNS-directed therapy and who have neurocognitive and behavioral/adaptive difficulties.