CORE--CLINICAL

临床服务核心的目标是支持一系列项目，检查可能与精神分裂症发病机制相关的临床表型和内在表型。具体而言，我们将研究1）一系列未经治疗的首发精神分裂症患者; 2）作为精神病对照组的首发非精神分裂症精神病受试者; 3）首发精神分裂症患者的成年一级亲属; 4）精神分裂症患者的青少年后代，其具有发展精神分裂症和相关精神障碍的高风险; 5）与患者及亲属来自同一社区的健康对照受试者。为了实现这些目标，临床服务中心将使用综合诊断和精神病理学评估组合（包括实验室和神经放射学评估）招募并描述研究受试者。将对患者进行为期6个月的随访，以建立诊断稳定性。所有数据将存储在由统计和数据管理核心-D管理的数据库中，中心研究者可访问。核心还将为脑库核心B配备工作人员并举行病例会议，以就所有尸检病例达成共识诊断。 获得脑标本。来自临床服务核心的数据将用于检验项目7-Carter和通过其他机制资助的相关项目中关于精神分裂症病因病理生理学的特定假设。

The goal of the Clinical Services Core is to support a range of projects that examine the clinical phenotypes and the endophenotypes that may be associated with the etiopathogenesis of schizophrenia. Specifically, we will study 1) a series of treatment-naive, first-episode schizophrenia patients; 2) first-episode non-schizophrenia psychotic subjects as a psychiatric comparison group; 3) adult first-degree family members of the first-episode schizophrenia patients; 4) adolescent offspring of schizophrenia patients at high risk for developing schizophrenia and related psychotic disorders; and 5) healthy comparison subjects from the same community as the patient and relative subjects. To address these goals, the Clinical Services Core will recruit and characterize the study subjects using a comprehensive diagnostic and psychopathological assessment battery, including laboratory and neuroradiological evaluations. The patients will be followed for six months to establish diagnostic stability. All data will be stored in a database managed by the Statistical and Data Management Core-D and will be accessible to Center investigators. The Core will also staff and conduct case conferences for the Brain Bank Core-B to achieve consensus diagnoses for all cases from whom post-mortem brain specimens are obtained. Data from the Clinical Services Core will be used to test the specific hypotheses regarding the etiopathophysiology of schizophrenia in Project 7-Carter and related projects funded through other mechanisms.