Time Resolved MRA of the Intracranial Vasculature

这项工作的广泛，长期目标是改善诊断和治疗的患者， 神经血管疾病诊断和治疗计划往往需要使用导管- X射线血管造影术（XRA）导管血管造影术是当前的参考标准， 颅内血管造影术，但使患者和医生暴露于高剂量的辐射， 需要动脉穿刺，注射肾毒性造影剂，并有轻微的风险， 中风使用动脉内导管进行XRA需要住院恢复，增加了 病人护理的费用。基于磁共振成像（MRI）的血管造影图像被广泛地应用。 可用，并减少了使用XRA诊断血管疾病，在许多血管 床然而，由于需要高帧图像（高达6帧/秒）来捕获团注， 尽管X射线血管造影是颅内血管动力学的一个重要组成部分，但X射线血管造影仍然是颅内血管成像的常规方法。我们正在开发 基于MRI的颅内XRA替代方案，基于使用径向采样和滑动窗口 重建MR血管造影的微创性将降低患者的风险 进行脑部诊断成像。使用我们的方法，磁共振血管造影可以达到 捕获通常被认为是不可能的团动态所需的帧和空间分辨率 用更具侵入性的XRA观察。在拟议的工作中，我们将实现我们的脉冲序列， 在体模、健康正常受试者中验证脉冲序列，并与XRA直接比较 在病人身上。我们将检验以下假设： 具体目标1：我们假设滑动窗口径向MRA可以更好地描绘血流 与传统的块式MRI采集相比， 具体目标2：我们假设约束径向滑动窗口图像的重建 采集将改善颅内血管的描绘，而不改变成像。 流动动力学 具体目标3：我们假设滑动窗口径向MRA可以准确地描述 患者的血管异常。 成功完成该项目后，我们将开发并验证一种非侵入性辅助物， 我们建议开发一种基于MRI的颅内X射线血管造影无创成像方案。 脉管系统我们的目标是开发一种脉冲序列，可以帮助诊断和治疗 计划广泛的神经血管疾病。目前解决这个问题的方法是导管- 基于X射线血管造影术，这是侵入性的，具有明确的中风风险， 和医生对电离辐射的认识。该项目的成功完成将导致更少的 进行侵入性成像程序，从而降低患者风险。

The broad, long-term goal of this work is to improve the diagnosis and treatment of patients with neurovascular disease. The diagnosis and treatment planning of often require the used of catheter- based x-ray angiography (XRA). Catheter angiography is the current referenced standard for intracranial angiography but exposes both the patients and physicians to high doses of radiation, requires an arterial puncture, the injection of nephrotoxic contrast agents and carries a slight risk of stroke. The use of intra-arterial catheters for XRA requires a hospital stay for recovery, adding to the cost of patient care. Magnetic Resonance Imaging (MRI) based angiographic images are widely available, and have reduced the use of XRA for the diagnosis of vascular disease in many vascular beds. However, due to the need of high frame images (up to 6 frames/sec) to capture bolus dynamics, XRA is still routinely performed to image the intracranial vasculature. We are developing an MRI-bases alternative to intracranial XRA based on using radial sampling and sliding window reconstruction. The minimally invasive nature of MR angiography will reduce the risk to patients undergoing diagnostic imaging of the brain. Using our approach to MR angiography can reach the frames and spatial resolution needed to capture the bolus dynamics that are normally observed with more invasive XRA. In the proposed work, we will implement our pulse sequence, validate the pulse sequence in phantoms, healthy normal subject, and in direct comparison with XRA in patients. We will test the following hypotheses: Specific Aim 1: We hypothesize that sliding window radial MRA can better depict flow dynamics than traditional block-wise MRI acquisitions. Specific Aim 2: We hypothesize that constrain reconstruction of radial sliding window images acquisition will improve the depiction of intracranial blood vessels without altering the imaging of flow dynamics. Specific Aim 3: We hypothesize that sliding window radial MRA can accurately depict the vasculature abnormalities in patients. Upon successful completion of this project we will have developed and validated a non-invasive adjunct to intracranial X-ray angiography We propose to develop an MRI-based imaging protocol for no-invasive imaging of the intracranial vasculature. Our goal is to develop a pulse sequence that can aid in the diagnosis and treatment planning of a wide range of neurovascular diseases. The current approach to this problem is catheter- based x-ray angiography which is invasive, carries a definite risk of stroke and subjects both patients and physicians to ionizing radiation. The successful completion of this project will results in fewer invasive imaging procedures being performed, resulting reduced risk to patients.