人类腺苷三磷酸双磷酸酶破坏癌症治疗-猫眼课题宝

人类腺苷三磷酸双磷酸酶破坏癌症治疗

批准号：

7599772

负责人：

RIDONG CHEN

金额：

$19.67万

依托单位：

APT THERAPEUTICS, INC.

依托单位国家：

美国

项目类别：

财政年份：

2008

资助国家：

美国

项目状态：

已结题

起止时间：

2008-09-12 至 2010-09-11

来源：

https://reporter.nih.gov/project-details/7599772

关键词：

Adhesions Antiplatelet Drugs Apyrase Aspirin Biological Assay Bleeding time procedure Blood Blood Platelets Blood Vessels Body Weight Bone Pain Breast Cancer Patient Cause of Death Cell Line Cell surface Cells Cessation of life Chinese Hamster Ovary Cell Clinic Clinical Colorectal Adenoma Colorectal Cancer Computer Assisted Culture Media Cytotoxic Chemotherapy Diagnosis Disease Dose Endothelial Cells Endothelium Endotoxins Engineering Enzymes Exhibits Fatty acid glycerol esters Funding Generations Genes Glioma Goals Grant Growth Guanosine Monophosphate Half-Life Hemorrhage Histologic Hormone Receptor Human Hydrolysis Immunocompetent In Vitro Incidence Informatics Invasive Laboratories Lead Life Luciferases Lung Malignant Neoplasms Malignant neoplasm of prostate Mammalian Cell Mammary gland Metastatic Neoplasm to the Bone Modeling Mus Neoplasm Metastasis Oral Outcome Pathway interactions Patients Pharmaceutical Preparations Phase Platelet Activation Platelet Glycoprotein GPIIb-IIIa Complex Platelet aggregation Preclinical Testing Prevention Production Prophylactic treatment Proteins Public Health Rattus Research Risk Safety Serum Subcutaneous Injections System Tail Testing Time Treatment Protocols Tumor Burden Tumor-Derived United States Universities Veins Washington adenoma aging population cancer cell cancer therapy clinically relevant day extracellular fluidity improved in vivo inhibitor/antagonist malignant breast neoplasm medical schools neoplastic cell novel novel therapeutics therapeutic protein vector

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中文摘要

翻译

描述(申请人提供)：人apyrase代表了一种非常有希望的抑制癌症转移的治疗方法。这种酶强烈抑制血小板的激活和聚集，而不会增加出血的风险。利用蛋白质信息学的方法，我们成功地设计了一个优化的人类apyrase，APT102。有了第一阶段的支持，我们将确定APT102单独或与阿司匹林联合使用在抑制小鼠实验性自发转移方面是有效的。公共卫生相关性：人类apyrase代表了一种非常有希望的癌症治疗方法。我们将确定靶向apyrase单独或与阿司匹林联合使用是否能有效抑制小鼠的实验性转移。

英文摘要

DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for inhibition of cancer metastasis. The enzyme strongly inhibits platelet activation and aggregation without increasing bleeding risk. Using a protein informatics approach, we have successfully engineered an optimized human apyrase, APT102. With the Phase I grant support, we will determine whether APT102, alone or in combination with aspirin, is effective in inhibiting experimental spontaneous metastasis in mice. PUBLIC HEALTH RELEVANCE:Human apyrase represents a highly promising therapy for cancer treatment. We will determine whether the targeted apyrase, alone or in combination with aspirin, is effective in inhibiting experimental metastasis in mice.

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