Clinical Evaluation of a Rebreathing Adsorber Mask to Facilitate Recovery from Vo

描述(申请人提供)：手术后，患者被转移到麻醉后护理病房，以完全从麻醉中恢复。在这段恢复期内发生不良临床事件的几率(24%)比在手术室发生的几率高得多，因为患者没有得到密切的监测。呼吸道阻塞是最常见的并发症。有严重呼吸事件的患者在重症监护病房停留的时间更长，意外进入重症监护病房的比率更高，更有可能出现心脏问题。我们建议开发和测试一种填充木炭的重复呼吸面罩，它可以加快麻醉蒸气的清除速度，缩短麻醉恢复时间。患者将更快地恢复正常的认知功能、血流动力学正常和反射，以保护呼吸道免受分泌物和阻塞的影响。他们将更快地获得幸福感，从而更早地从麻醉后护理病房出院。我们将用肺/气体交换模拟器测试一个原型装置，并对44名患者进行临床试验，测量他们在术后24小时内的恢复率和危重事件的发生率。如果成功，填充木炭的再呼吸面罩有可能将患者在麻醉后护理病房的停留时间缩短20分钟，并将危重事件发生的风险降低60%。与公共卫生相关：使用重复呼吸面罩来加快麻醉后的恢复速度，可能会降低美国每年进行的2000万例全身麻醉手术的总成本。将恢复时间缩短20分钟可能会使患者在PACU的住院费用减少110美元，并将麻醉后危重事件的风险降低60%。

DESCRIPTION (provided by applicant): After surgery patients are transferred to a post anesthesia care unit to fully recover from anesthesia. There is a much higher chance of an adverse clinical event occurring during this recovery time (24%) than in the operating room because patients are not as closely monitored. Airway obstruction is the most frequent complication. Patients with a critical respiratory event stay longer in the care unit, have higher rates of unanticipated admission to an intensive care unit and are more likely to have cardiac problems. We propose to develop and test a charcoal filled rebreathing mask that accelerates the rate of removal of anesthetic vapors and shortens anesthesia recovery time. Patients will more quickly regain normal cognitive function, homodynamic normalcy and reflexes to allow for airway protection from secretions and obstruction. They will more quickly gain a sense of well being resulting in earlier discharge from the post anesthesia care unit. We will test a prototype device with a lung/gas exchange simulator and conduct a clinical trial with 44 patients, measuring their rate of recovery and the incidence of critical events during the first 24 hours after surgery. If successful, the charcoal filled rebreathing mask has the potential to shorten the patients stay in the post anesthesia care unit by 20 min and reduce the risk of a critical event occurring by 60%. PUBLIC HEALTH RELEVANCE: Use of the rebreathing mask to speed recovery after anesthesia could potentially reduce the overall cost of each of the 20 million general anesthetic procedures performed in the United States each year. Reducing the recover time by 20 min might decrease the cost of a patient's stay in the PACU by $110 and reduce the risk of post anesthesia critical events by 60%.