Novel Liquid Adhesive Bandages for Acceleration of Partial-Thickness Wound Healin

描述(由申请人提供)：这个小型企业创新研究(SBIR)第一阶段项目为罗查工业，有限责任公司是开发一种新型液体粘合绷带的可行性，以帮助部分厚度的伤口愈合。这种新型液体粘合绷带在干燥和潮湿的表面上形成一层半闭塞、顺应性、粘附性的聚合物薄膜，无刺痛、不灼伤，并具有氧气和水蒸气渗透性。体外初步研究表明，这些液体绷带中的某些可以产生透明的、不溶于水的薄膜，作为人类表皮角质形成细胞和人类皮肤成纤维细胞生长的支架。这项建议的目的是确定哪种新型液体粘合绷带组合物在提供最大程度的加速部分厚度伤口愈合方面最有效。目前还没有商业上可用的、紧密符合的液体粘合绷带作为伤口愈合的一种手段来支持细胞生长。这项研究中独特的聚合物涂层可能会对它们在伤口护理敷料中的使用产生重大影响。迈阿密大学皮肤科和皮肤外科的伤口愈合和感染研究实验室将根据所提供的首选液体粘合绷带配方，在猪的深度部分伤口模型上进行炎症评估和伤口愈合方案。这种猪模型已经在许多伤口护理产品上得到了使用和验证，包括水胶、水凝胶、透明薄膜和闭塞敷料。优化后的配方将被考虑用于第二阶段测试。Rochal Industries，LLP的姊妹公司Rochal Industries，Inc.之前发明了一种基于硅氧烷的液体粘合绷带，该绷带由3M公司授权并商业化(3M Cavilon No Sting Barrier膜用于医院和疗养院，3M Nexare喷雾液体绷带No Sting用于非处方药)。虽然商业化的绷带不具备目前提议的绷带的独特性能，但目前的公司非常熟悉通过授权实现商业化的过程。

DESCRIPTION (provided by applicant): This Small Business Innovation Research (SBIR) Phase I project for Rochal Industries, LLP is to develop feasibility of a novel liquid adhesive bandage for assisting partial-thickness wound healing. This new class of liquid adhesive bandage forms a semi-occlusive, conformable, adherent polymer film on dry and moist surfaces that is non-stinging and non-burning, as well as oxygen- and water vapor-permeable. In vitro preliminary studies have shown that certain of these liquid bandages yielded clear, water-insoluble films that served as a scaffold for growth of human epidermal keratinocytes and human skin fibroblasts. It is the intent of this proposal to determine which novel liquid adhesive bandage composition is most efficacious in providing the greatest acceleration of partial-thickness wound healing. No commercially available, intimately conforming, liquid adhesive bandage has been shown to support cell growth as a means of wound healing. The unique polymer coatings of this research could have a major impact on their use in wound care dressings. The Wound Healing & Infection Research Laboratories of the Department of Dermatology & Cutaneous Surgery of the University of Miami will conduct inflammatory assessment and wound healing protocols on a pig model for deep partial-thickness wounds based upon the preferred liquid adhesive bandage formulations provided. This pig model has been used and validated on numerous wound care products, including hydrocolloids, hydrogels, transparent films, and occlusive dressings. The optimized formulation will be considered for Phase II testing. Rochal Industries, Inc., a sister company of Rochal Industries, LLP, previously invented a siloxanyl-based liquid adhesive bandage that was licensed and commercialized by 3M Company (3M Cavilon No Sting Barrier Film, for hospital and nursing homes, and 3M Nexcare Spray Liquid Bandage No Sting, for OTC). Although the commercialized bandage does not have the unique properties of the currently proposed bandages, the current company is well acquainted with the process of commercialization through licensing.