Assessment of viral loads as markers of disease status

近年来，美国艾滋病和艾滋病相关癌症的总体死亡率显著下降，但这种下降并不是在所有人群中一致的。由于在护理方面存在一系列障碍，感染了I型人体免疫缺陷病毒（艾滋病毒）和其他各种性传播疾病（即8型人类疱疹病毒[HHV-8]和人乳头瘤病毒[HPV]）的少数民族和穷人没有像其他群体那样从艾滋病毒和与艾滋病毒相关疾病的治疗进展中受益。少数民族感染艾滋病毒（和其他性传播传染病）的比率远远高于白种人。非洲裔美国妇女是艾滋病毒阳性人群中增长最快的群体。我们的建议是通过在研究人员、已建立的卫生保健机构、社区外展团体和教育倡议之间建立伙伴关系来解决这一问题，以缩小这些哲学差异中的差距，认识到局限性，并向医学界、研究人员和公众伸出援助之手，以缩小健康差距。它特别侧重于整合不同群体之间的资源，以最大限度地为南卡罗来纳州服务不足的人群提供医疗保健。我们相信，这项研究的结果将使全国所有服务不足的群体受益。1)建立一个分子病毒学实验室，作为EXPORT合作研究人员的核心研究资源；2)收集和提供HIV-1血清阳性个体的HIV-1数据，参与博士项目。汉德，菲利普斯和博士。Stoskopf和Geslani， 3)提供HPV 16和18e7 mRNA的定量评估，HPV的测序和基因分型，以及从巴氏涂片收集的HPV病毒载量。Creek和Pirisi， 4)测定HIV-1血清阳性患者的HHV-8病毒载量

In recent years, the overall AIDS and AIDS associated cancer mortality in the U.S. has significantly decreased, but the decrease has not been consistent across all populations. Due to an array of barriers to care, minorities and poor people who are infected with the human immunodeficiency virus type I (HIV) and various other sexually transmitted diseases (i.e., human herpes virus type 8 [HHV-8] and human papillomavirus [HPV]) have not benefited from advances in the treatment of HIV and HIV associated diseases as other groups. Minorities are acquiring HIV (and other sexually transmitted infectious diseases) at much higher rates than observed in Caucasians. African American (AA) women are the fastest growing group of HIV positive individuals. Our proposal addresses this issue by developing a partnership between the researchers, the established health care facilities, community outreach groups and education initiatives to close the gaps in these philosophical differences, realize the limitations, and reach out to the medical community, researcher, as well as the public to reduce the health disparities. It focuses specifically on consolidation of the resources between various groups to maximize health care for the underserved populations in SC. We believe that the outcome of this study will benefit all the underserved groups in the nation The five specific aims of this project are: 1) to establish a molecular virology laboratory to serve as a core research resource for the EXPORT collaborating researchers 2) to collect and provide data on HIV-1 in HIV-1 seropositive individuals recruited for participation in the projects of Drs. Hand and Phillips and Drs. Stoskopf and Geslani, 3) to provide quantitative assessment of HPV 16 and 18 E7 mRNA, sequencing and genotyping of HPV, and HPV viral load from Pap smears collected from the other full research project headed by Drs. Creek and Pirisi, 4) to determine HHV-8 viral loads in HIV-1 seropositive individuals for this research project and then to 5) investigate any correlation(s) between the development of full blown AIDS, and KS.