Identification and erradication of pre-malignant B cells in the prevention of lymphoma

B细胞淋巴瘤是成人中最常见的一种非霍奇金淋巴瘤，尽管治疗有所改善，但仍有40-50%的患者死于这种疾病。T细胞在预防B细胞淋巴瘤的发展中起着至关重要的作用。在这个项目中，我们的目标是确定B细胞淋巴瘤的早期阶段和逃避T细胞控制的机制，最终目的是将这些发现转化为人类研究，以改善疾病的诊断、治疗和预后。

B Cell Lymphoma is the most frequent type of non-Hodgkin lymphoma in adults and despite improved treatment, 40-50% of patients succumb to their disease. T cells are critical in the in the prevention B cell lymphoma development. In this project we aim to identify the earliest stages of B cell lymphoma and mechanisms of escape from T cell control with the ultimate aim to translate these findings to human studies to improve disease diagnosis, treatment and prognosis.