Core--Lung imaging

(申请人摘要)成像的最新进展现在为我们提供了一种 增进我们对关系的了解的绝佳机会 慢性阻塞性肺疾病患者的细胞功能与空气生理之间的关系 哮喘。成像核心的主要任务是将 新兵呼吸道结构、生理、病理与功能的关系 手机。从人类和动物研究中获得的成像数据将是 与项目I-V中获得的生理和细胞数据相关联。我们的 具体目的是：1)评估嗜酸性粒细胞对呼吸道的影响 超极化氦-3(3He)磁共振肺通气成像的生理学研究 在人类和动物哮喘模型中，2)确定区域分布 人和动物哮喘模型中代谢活性嗜酸性粒细胞的研究 18FDG PET，以及3)将来自PET的代谢和生理数据进行联合登记 使用来自肺部高分辨率CT扫描的解剖信息的磁共振成像。 由于许多提议的技术都是新技术，核心C将负责 开发和执行建议的成像方法。

(Applicant's Abstract) Recent advances in imaging now provide us with an outstanding opportunity to improve our knowledge about the relationship between cellular function and physiology of the airspaces in patients with asthma. The primary mission of the Imaging Core is to correlate changes in airway structure, physiology, and pathology with function of the recruited cell. The imaging data gained from the human and animal studies will be correlated with physiologic and cellular data obtained in Projects I-V. Our specific aims are to; 1) evaluate the influence of eosinophils on airway physiology using hyperpolarized helium-3 (3He) MR imaging of lung ventilation in human and animal models of asthma, 2) determine the regional distribution of metabolically active eosinophils in human and animal models of asthma using 18FDG PET, and 3) co-register the metabolic and physiologic data from PET and MRI using anatomic information from high-resolution CT scanning of the lungs. Since many of the proposed techniques are new, CORE C will be responsible for developing and performing the proposed imaging methods.