SYNTHESIS OF NOVEL PRECURSORS TO PROPOSED ANTIBACTERIAL AGENTS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项工作将利用合成化学工具，以产生新的杂环化合物，将被检查为可能的前体，拟议的聚酯抗菌大环。 将使用惰性歧管制备化合物，并通过标准光谱法和光谱学方法进行检查，包括FTIR、FTNMR和GCMS。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This work will utilize synthetic chemistry tools to produce novel heterocyclic compounds that will be examined as possible precursors for a proposed polyester antibacterial macrocycle. The compounds will be prepared with an inert manifold and examined via standard spectrometry and spectroscopy methods to include: FTIR, FTNMR, and GCMS.