COBRE P5: RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND TYPE 2 DIABETES

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究项目的目的是测试假设牙周病的治疗与更好的糖尿病血糖控制（HbA 1c）和较低水平的催化活性形式的MMP-8在讲Gullah的非洲裔美国人的患者。 我们将对这一居住在南卡罗来纳州海岸海岛上的遗传混杂最少的人群进行干预性研究。 有三个具体目标。 第一个目标是证明牙周病进展控制不良的2型糖尿病患者Gullah比控制良好的患者更严重。 第二个目标是评估牙周治疗对古拉人群血糖控制水平的影响。 第三个目标是评估MMP-8的催化活性形式在基线（牙周干预之前）和3个月和6个月后的浓度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research project is to test the hypothesis that treatment of periodontal disease is associated with better diabetes glycemic control (HbA1c) and lower levels of the catalytically active form of MMP-8 in the Gullah-speaking African American patients. We will conduct an interventional study on this population with minimal genetic admixture, living on the Sea Islands of the South Carolina coast. There are three specific aims. The first aim will demonstrate that periodontal disease progression on poorly controlled Type 2 diabetic Gullah patients is more severe than on well-controlled patients. The second aim will assess the effects of periodontal therapy on the level of glycemic control in the Gullah population. The third aim will assess the concentration of the catalytically active form of MMP-8 at baseline (prior to periodontal intervation) and 3 and 6 months later.