IDENTIFICATION OF IFT PARTICLE COMPONENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们研究的目的是了解纤毛结构是如何产生的，以及它们是如何发挥作用的。我们在C中探讨这个问题。优雅所有的纤毛都是通过鞭毛内运输（IFT）过程形成的。我们将使用质谱法来鉴定来自C.秀丽隐翅虫我们希望新的睫状体成分的鉴定将使我们能够进一步了解睫状体功能障碍如何导致发育障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of our research is to understand how ciliary structures are generated, and how they function. We are exploring this issue in C. elegans. All cilia are formed by the process of intraflagellar transport (IFT). We will use mass spectrometry to identify IFT particle components from C. elegans cilia. We expect that identification of new ciliary components will allow us to further understand how ciliary dysfunction leads to developmental disorders.