STYLOPEPTIDE 2, PROLINE-RICH CYCLODECAPEPTIDE FROM SPONGE STYLOTELLA SP

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 从海洋来源分离的非核糖体环肽的数量继续增长。 这样的肽对于酶促降解相对稳定，并且由于它们的极性较低，比它们的线性表兄弟更具生物学可利用性。 富含脯氨酸的环肽是最近出现的一类新的环肽。 该组的大多数成员是海绵衍生的七肽或八肽，其具有散布在脯氨酸之间的非极性氨基酸残基（通常具有一个或两个芳香族代表）。 实例包括axinellins、axinastatins、hymenamides、phakellistatin、stylopeptide和wainunuamide。Phakellistatin是富含脯氨酸的环状十肽的实例。 我们已经分离并鉴定了一种新的富含脯氨酸的十肽，stylopeptide 2，其从提供stylopeptide和stylostatin的柱孢菌属的同一集合中获得。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of non-ribosomal cyclic peptides isolated from marine sources continues to grow. Such peptides are relatively stable toward enzymatic degradation and, with their less polar nature, are more biologically available than their linear cousins. Proline-rich cyclopeptides constitute a new class that has recently emerged. Most members of this group are sponge-derived hepta- or octapeptides with non-polar amino acid residues (usually with one or two aromatic representatives) interspersed among the prolines. Examples include the axinellins, axinastatins, hymenamides, phakellistatins, stylopeptide and wainunuamide. Phakellistatins are examples of proline-rich cyclic decapeptides. We have isolated and characterized a new proline-rich decapeptide, stylopeptide 2, obtained from the same collection of Stylotella sp. that provided stylopeptide and stylostatin.