REMOTE PROTEIN SEQUENCE HOMOLOGY DETECTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本计画的目标是发展一种新的远端蛋白质序列同源性侦测演算法。我们的方法涉及开发一种更准确的轮廓-轮廓比对算法，用于检测目标查询蛋白中的Pfam（http：//www.sanger.ac.uk/Software/Pfam/）结构域。我们建议使用TeraGrid来生成蛋白质序列图谱，使用修改的PSI-BLAST算法对来自Pfam-A和Pfam-B家族的20万个代表性序列进行分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to develop a novel algorithm for remote protein sequence homology detection. Our approach involves developing a more accurate profile-profile alignment algorithm for detecting Pfam (http://www.sanger.ac.uk/Software/Pfam/) domains in a query protein of interest. We propose to use the TeraGrid to generate protein sequence profiles on 200,000 representative sequences from the Pfam-A and Pfam-B families using a modified PSI-BLAST algorithm.