KATP CHANNEL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的主要目标是获得KATP通道开放构象和闭合构象的中等分辨率结构。 KATP通道是一种代谢传感器，它将葡萄糖代谢的变化与膜上的电活动联系起来。在胰岛β细胞中，KATP依赖的膜去极化导致胰岛素的下游释放。该通道的突变与广泛的代谢紊乱有关，包括新生儿糖尿病、2型糖尿病和婴儿期持续性高胰岛素血症低血糖。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary goal of the project is to obtain intermediate resolution structures of the open and closed conformations of the KATP channel. The KATP channel is a metabolic sensor that couples changes in glucose metabolism to membrane electrical activity. In the pancreatic beta cell, KATP dependent membrane depolarization leads to downstream insulin release. Mutations in the channel have been implicated in a wide range of metabolic disorders including neonatal diabetes, type 2 diabetes, and persistent hyperinsulinemia hypoglycemia of infancy.