Identification and molecular characterisation of high-risk premalignant breast lesions

了解乳腺癌发生的全部基因事件可能有助于制定预防策略。这项研究将分析良性乳腺病变的遗传数据，这些病变可能是乳腺癌的非专性先兆。重要的是，这些病变的临床处理是困难的。一种可靠的预测癌症进展风险的方法将是一个重大的进步，对个别患者和卫生系统都有好处。

Understanding the full repertoire of genetic events that underlie the development of breast cancer may allow development of prevention strategies. This study will analyse genetic data of benign breast lesions that may be non-obligate precursors of breast cancer. Importantly, clinical management of these lesions is difficult. A reliable method of predicting the risk of progression to cancer would be a significant advance, with benefits to individual patients and also the health system.