GhREAT: Global health Research Expanding Advanced Training

描述(由申请者提供)：该项目的目标是利用凯斯西储大学(CWRU)现有的研究计划和框架计划，并扩大现有的关系和合作，加快全球卫生研究领域博士后培训生的发展。有三所学校/学院参与(医学院：全球卫生与疾病中心和流行病与生物统计学系，文理学院：人类学系和护理学院。)这三所学校自2007年以来一直在FIC资助的框架项目上进行合作。作为该项目的结果，已经成功地提供了合作课程，开发了全球卫生领域的跨学科教育证书方案，并与三个单位的调查人员一起指导了国际研究项目。目前的提议将这些成功转化为合作伙伴未能获得资金的博士后培训机会。本建议的独特之处在于，我们在消除淋巴丝虫病(LF)方面使用了新资助的随机对照试验，并增加了患者自我管理科学中的行为科学成分，以更好地了解随机对照试验参与者对低收入国家/地区(巴布亚新几内亚和撒哈拉以南非洲)丝虫病治疗的整体反应。RCT正在测试不同剂量和组合的药物，以实现消除的终点。我们在这里建议的是一个跨学科的博士后培训计划，以便来自三个学科、具有不同护理方法的受训人员将更好地了解参与者的治疗经验，长期目标是确定使治疗有效和抑制治疗有效性的因素。这些因素不仅仅是副作用，还可能包括参与者对药物有效性的看法，治疗是否有社会影响，参与者在患有丝虫病时如何进行自我管理，以及LF对社会和社区的影响。此外，受训人员将在克利夫兰和全球卫生站点的CWRU调查人员的支持下，在研究支持环境中获得较长期的全球卫生实地经验(9个月)。 公共卫生相关性：淋巴丝虫病是一种被忽视的热带疾病，对感染者的生活有重大影响，包括耻辱、工作和社会角色的限制以及社会影响。拟议的项目打算提供博士后培训，为LF提供自我管理科学方面的研究培训，以扩大凯斯西储大学的博士后全球卫生培训。

DESCRIPTION (provided by applicant): The aims of this project are to accelerate the development of post-doctoral trainees in global health research, taking advantage of existing research programs and the Framework program at Case Western Reserve University (CWRU) and expanding existing relationships and collaborations. There are three Schools/Colleges participating (School of Medicine: Center for Global Health and Disease and Department of Epidemiology and Biostatistics, College of Arts & Sciences: Department of Anthropology and School of Nursing.) These three schools have been collaborating since 2007 on a FIC-funded Framework project. As a result of that project, there have been successful collaborative course offerings, development of an interdisciplinary educational certificate program in global health, and mentored international study projects with investigators from each of the three units. The current proposal leverages these successes into post- doctoral training opportunities where the partners have not been able to secure funding. The unique aspect of the present proposal is that we are using newly funded RCTs in lymphatic filariasis (LF) elimination and adding behavioral science components from the science of patient self-management to better understand how RCT study participants respond holistically to treatment for filariasis in low income countries/regions (Papua New Guinea and Sub-Saharan Africa). The RCTs are testing different doses and combinations of medications in order to achieve endpoints for elimination. What we propose here is an interdisciplinary post- doctoral training program so that trainees from three disciplines with distinct approaches to care will better understand the participant experience of treatment with the long term goal of identifying factors that enable and inhibit treatment effectiveness. These factors go beyond side effects but also may include participant perceptions of the effectiveness of the drugs, whether there are social impacts from therapy, how participants perform self-management when they have filariasis, and social and community impacts from LF. In addition, the trainees will have longer-term field experiences (9 months) in global health in a research- supportive environment and with the support of the CWRU investigators in Cleveland and global health sites PUBLIC HEALTH RELEVANCE: Lymphatic filariasis (LF) is a neglected tropical disease that has substantial impact on the lives of those affected, including stigma, limitations in jobs and social roles and social impacts. The proposed project intends to provide post-doctoral training providing research training for LF with the science of self- management to expand post-doctoral global health training at Case Western Reserve University.