Vitamin D Production by Sperti Lamp in Fat Malabsorption Patients

描述（由申请人提供）：维生素D在儿童和成人的钙代谢和骨骼健康中起着关键作用。现在认识到，体内的每个组织和细胞都有维生素D受体，因此体内的每个组织和细胞都是维生素D作用的靶点。研究表明，增加阳光照射和增加维生素D摄入量可以降低许多慢性疾病的风险，包括自身免疫性疾病，心脏病，传染病，II型糖尿病和癌症。维生素D缺乏和不足是美国儿童和成人最常见的营养缺乏和医疗状况。儿童和成人维生素D的主要来源是暴露在阳光下。饮食中几乎没有维生素D，因此要保持正常健康的维生素D状态，需要服用维生素D补充剂。吸收不良的患者以及体弱且无法暴露在任何阳光下的儿童和成人患维生素D缺乏症及其健康后果的风险特别高。人工紫外线照射也是维生素D的良好来源。KBD Inc. Sperti是一家生产维生素D生产灯的小企业，该生产灯已经存在了50多年，并用于生产维生素D。该灯已被修改，使大部分的光谱输出是在UVB区域，从而最大限度地产生维生素D。这项资助的目的是利用这种新设计的灯，并测试其在炎症性肠病患者中产生维生素D的有效性，这些患者已被证明吸收维生素D不良。皮肤类型为2、3、4和5的成人IBD患者将暴露于Sperti荧光灯的UVB辐射，每周三次，持续三个月。血液中25-羟基维生素D的水平是维生素D状态的一个指标，将是这项研究的主要结果。这项研究的结果应该提供有效性数据，以支持这种新型维生素D生产荧光灯的商业开发，不仅适用于吸收不良综合征患者，也适用于疗养院的老年人以及无法暴露在阳光下且难以服用维生素D补充剂的儿童和成人。 公共卫生相关性：这项资助的目的是获得数据，表明接触一种新型的Sperti荧光维生素D生产灯可有效改善患有炎症性肠病的患者的维生素D状况，这些患者已记录了维生素D吸收不良。预计这笔赠款的结果将为小企业KBD Inc.提供动力。向患有肠道吸收不良综合症和缺乏维生素D的患者推销和销售其产品。

DESCRIPTION (provided by applicant): Vitamin D plays a critical role in calcium metabolism and bone health in children and adults. It is now recognized that every tissue and cell in the body have a vitamin D receptor and thus every tissue and cell in the body is a target for vitamin D action. Studies suggest that increased exposure to sunlight and increased vitamin D intake reduces risk of many chronic diseases including autoimmune diseases, heart disease, infectious diseases, type II diabetes and cancer. Vitamin D deficiency and insufficiency is the most common nutritional deficiency and medical condition in children and adults throughout the United States. The major source of vitamin D for children and adults is exposure to sunlight. There is little vitamin D in the diet and thus to maintain a normal healthy vitamin D status requires taking a vitamin D supplement. Patients with malabsorption and children and adults who are infirm and unable to be exposed to any sunlight are at particularly high risk for vitamin D deficiency and its health consequences. Artificial ultraviolet irradiation is also a good source of vitamin D. KBD Inc. is a small business that makes the Sperti vitamin D producing lamp that has been in existence for more than 50 years and marketed for producing vitamin D. The lamp has been modified so that most of the spectral output is in the UVB region thus maximally producing vitamin D. The goal of this grant is to take this newly designed lamp and test its effectiveness in producing vitamin D in patients with inflammatory bowel disease who have been demonstrated to malabsorb vitamin D. Adult IBD patients with skin types 2,3,4 and 5 will be exposed to suberythemal dose of UVB radiation from the Sperti fluorescent lamp three times a week for three months. Blood levels of 25-hydroxyvitamin D, a measure of vitamin D status, will be the primary outcome for the study. Results from this study should provide efficacy data to support the commercial development of this novel vitamin D producing fluorescent lamp not only for patients with malabsorption syndromes but also elderly in nursing homes and for children and adults who cannot be exposed to sunlight and have a difficult time taking a vitamin D supplement. PUBLIC HEALTH RELEVANCE: The goal of this grant is to obtain data that exposure to a novel Sperti fluorescent vitamin D producing lamp is effective in improving the vitamin D status of patients with inflammatory bowel disease who have documented vitamin D malabsorption. It is anticipated that results from this grant will provide the impetus for the small business KBD Inc. to market and sell its product to patients who suffer from the intestinal malabsorption syndromes and who are vitamin D deficient.