Core--Informatics and statistical genetics

计划项目赠款(PPG)的信息学和统计遗传学核心(ISGC)研究将在与PPG的生物信息学、计算生物学、数学建模、数据分析和群体遗传学方面相关的一些领域提供新的方法开发和指导。ISGC研究人员将包括参与与该联盟有关的6个应用项目的研究小组成员以及其他联盟成员。ISGC的具体目标是：与分子基因组学核心(MGC)一起向PPG提供应用生物信息学和序列分析支持，通过监督和实施各种操作，例如， 数据库搜索多态信息，用于基因分型分析开发的侧翼序列识别，新序列发现的同源性搜索，序列信息的进化分析等。提供计算生物学支持和选择用于研究的基因的多态的电子分析。这些活动包括酌情将非同义的cSNPs映射到蛋白质上，通过对接实验评估蛋白质的相互作用，以及维护一个网站，提供详细说明这些活动的相关信息，以便为PPG研究提供广泛的服务。提供数据分析支持，特别是在单倍型分析、上位性相互作用分析、双胞胎分析等领域开发新的数据分析方法。提供群体遗传分析的设计、监督和解释，最主要的是那些用于评估潜在遗传分层和研究样本的隐蔽样本亚结构的分析。尽管我们在下文中详述了ISGC的活动，但我们要强调的是，ISGC提供的一些信息以及与ISGC相关的其他信息已被纳入MGC、人类表型/双胞胎核心、生物化学核心、行政核心(AC)以及6个单独研究项目的描述中。考虑到篇幅限制和ISGC活动的性质，我们合并了初步研究和实验设计与方法部分(C和D部分)，并在下文B部分侧重于组织，并通常在提案末尾省略关于人类主题的部分等。

The Informatics and Statistical Genetics Core (ISGC) of the Program Project Grant (PPG) research will provide novel methodological developments and guidance in a number of areas of relevance to bioinformatics, computational biology, mathematical modeling, data analysis, and population genetics aspects of the PPG. The ISGC researchers will include members of the research teams involved in the 6 applied projects associated with the Consortium as well as additional Consortium members. The specific aims of the ISGC are to: Provide applied bioinformatics and sequence analysis support to he PPG in conjunction with the Molecular Genomics Core (MGC), by overseeing and implementing a variety of operations, e.g., database searches for polymorphism information, flanking sequence identification for genotyping assay development, homology searches for novel sequence findings, evolutionary analysis of sequence information, etc. Provide computational biology support and in silico analysis of polymorphism in the genes chosen for study. These activities include mapping non-synonymous cSNPs onto proteins, where appropriate, and assessing protein interactions via docking experiments, as well as maintaining a WEB site supplying relevant information detailing these activities in order to serve the PPG research broadly. Provide data analysis support and, in particular, novel data analysis methodology development in areas such as haplotype analysis, epistatic interaction analysis, twin analysis, etc. Provide design, oversight, and interpretation of population genetic assays, most notably those used to assess potential genetic stratification and cryptic sample substructure with the study samples. Although we detail activities of the ISGC below, we want to emphasize that some information provided by the ISGC, as well as additional information of relevance to the ISGC, has been integrated into the descriptions of the MGC, the Human Phenotyping/twins Core, the Biochemistry Core, the Administrative Core (AC), as well as the 6 individual research projects. Given page limitations and the nature of the ISGC activities, we have combined the Preliminary Studies and Experimental Design and Methods Sections (sections C and D) and focus on organization in section B, below, and omit sections on Human Subjects, etc. normally at the end of the proposal.