Depression Subtypes: Cognition, Emotion, Neurophysiology

描述（由申请人提供）：最近的抑郁症模型概述了抑郁症中边缘、情绪处理和突出脑区域之间的关系，假设额顶叶、执行控制脑区域无法调节这些边缘区域。然而，尽管有这些理论主张，在功能成像过程中，仍然缺乏认知和情绪挑战研究来评估抑郁症中这些被提出的被破坏的情绪处理和执行调节回路。此外，围绕抑郁症是单一实体还是具有不同临床亚型的异模实体模型的争议使抑郁症研究复杂化。目前的建议是，在实验对象完成情绪处理和执行功能任务时，对比fMRI的表现和激活，以确定参与这些过程的大脑回路。此外，焦虑症状的类型和严重程度在建议中使用维度方法进一步探讨。首席研究员（PI） Scott Langenecker博士提议在继续教育活动的背景下开展这项研究，旨在发展统计模型，功能MRI物理和抑郁症亚型方面的专业知识。在他的导师Jon-Kar Zubieta医学博士和他的共同导师Doug Noll博士的帮助下，Langenecker博士召集了广泛的研究人员和统计学家来协助这项工作。这个K奖允许研究方向的改变，从健康衰老的功能成像工作，到解决抑郁症的执行功能和情绪调节。专业知识是必要的，以充分利用功能性MRI来了解抑郁症的神经生理学，包括认知和情感挑战。指导和合作关系提出了一些杰出的研究人员在抑郁症和功能成像。短期目标是扩大Pis知识库，同时完成拟议的研究。长期目标是提高抑郁症诊断亚型的准确性和可靠性，理解抑郁症情绪的调节和经验方面之间的关系，并利用这些机制来增强治疗匹配范式。充足的理论背景、严谨的方法和强有力的初步数据支持本项目的假设和目标。R01提案计划在提议项目的第三年结束时，作为Pis独立研究事业发展的跳板。密歇根大学抑郁症研究中心为开展这项研究提供了一个出色的媒介，为PI和他的团队提供了一群杰出的抑郁症研究人员。

DESCRIPTION (provided by applicant): Recent models of depression have outlined a relationship between limbic, emotion processing and salience brain regions in depression, with the hypothesis that fronto-parietal, executive control brain regions are unable to regulate these limbic regions. Yet, despite these theoretical claims, there remains a paucity of cognitive and emotion challenge studies during functional imaging to assess these proposed disrupted emotion-processing and executive-regulatory circuits in depression. Further, complicating depression research is the controversy surrounding the model of depression as unitary or heteromodal entities, with different clinical subtypes. The current proposal contrasts performance and activation during fMRI while subjects complete an emotion processing and an executive functioning task to determine brain circuits involved in these processes. In addition, type and severity of anxiety symptoms is further explored in the proposal using a dimensional approach. The principal investigator (PI), Scott Langenecker, Ph.D., has proposed to carry out this research in the context of continuing education activities directed towards developing expertise in statistical models, functional MRI physics, and depression subtypes. With the assistance of his mentor, Jon-Kar Zubieta, M.D., Ph.D., and his co-mentor, Doug Noll, Ph.D., Dr. Langenecker has assembled a broad range of researchers and statisticians to assist in this endeavor. This K award allows for a change in research direction, from functional imaging work in healthy aging, to address executive functioning and emotion regulation in depression. Expertise is necessary to fully exploit functional MRI to understand the neurophysiology of depression, including cognitive and emotional challenges. Mentorship and collaborative relationships are proposed with a number of exceptional researchers in depression and functional imaging. Short-term goals address expansion of the Pis knowledge base, while completing the proposed study. Long term goals address increasing diagnostic subtyping accuracy and reliability for depression, understanding the relationship between regulatory and experiential aspects of emotion in depression, and using these mechanisms to enhance treatment matching paradigms. Sufficient theoretical background, methodological rigor, and strong preliminary data support the hypotheses and aims of this project. An R01 proposal is planned for the end of year three of the proposed project, as a springboard to the development of the Pis independent research career. The University of Michigan Depression Center provides an outstanding medium for pursuing this study, with an exceptional cohort of depression researchers available to the PI and his assembled team.