Treatment of Emotional Disorders in Adolescence

描述（由申请人提供）：本申请是对NIMH指导的以患者为导向的研究职业发展奖（K23）的请求，以促进申请人Jill T的学术职业发展。Eughreich博士申请人将与她的主要导师大卫巴洛博士，她的共同导师温迪西尔弗曼博士和专家顾问劳拉·穆夫森博士，约翰·韦兹博士，詹姆斯·格罗斯博士，理查德·勒纳博士和蒂莫西·布朗博士合作，发展进行临床研究的专业知识，为青少年情绪障碍建立创新和有效的干预措施。在一个跨越五年的职业发展计划中，申请人已经划定了短期和长期目标，为她以病人为导向的研究生涯做好准备。短期目标包括在选定的几个“核心”领域获得教学培训和指导，以加深她现有的技能，并将她的技能扩展到新的领域。申请人的长期目标是开发一系列项目性研究，重点是开发儿童和青少年焦虑症及其最常见的共病的创新治疗方法，并开始作为临床科学家的高效职业生涯。提出了一个正式的研究计划，以调查青春期的情绪障碍，特别是焦虑症和单极情绪障碍。尽管理论和研究表明这些疾病可能具有共同的生物和心理脆弱性，彼此表现出高度的共病性，并证明对发育的潜在慢性影响，但很少有治疗研究调查单一方案的有效性，适用于治疗青春期的这一系列疾病。拟议研究计划的主要目标是开发和应用一种新的治疗青少年情绪障碍的方法，该方法基于对青少年焦虑和抑郁的有效治疗以及对成人的现有干预，该干预将适用于各种情绪障碍干预的基本治疗成分结合起来。该项目的主要目标是：（1）为表现出一系列情绪障碍的青少年创造一种新的治疗方法，称为青少年抑郁和焦虑治疗方案;（2）对15名表现出焦虑和/或单极情绪障碍的青少年使用该方案进行一项小型开放试验;以及，（3）在一项对60名患有焦虑和/或单相情绪障碍的青少年进行的试点研究中建立ADAPT项目的初始效应量，并评估治疗后3个月和6个月的变化维持情况。由此产生的治疗可能会产生深远的影响，通过传播给社区提供者治疗青少年的焦虑和抑郁症，凭借其相对一致的格式，加上其广泛的应用。

DESCRIPTION (provided by applicant): This application is a request for a Mentored Patient-Oriented Research Career Development Award (K23) from the NIMH to foster the academic career development of the applicant, Jill T. Ehrenreich, Ph.D. The applicant will work with her primary mentor, Dr. David Barlow, her co-mentor, Dr. Wendy Silverman, and expert consultants, Dr. Laura Mufson, Dr. John Weisz, Dr. James Gross, Dr. Richard Lerner, and Dr. Timothy Brown, to develop expertise in conducting clinical research to establish innovative and efficacious interventions for adolescents with emotional disorders. In a career development plan spanning five years, the applicant has delineated short-term and long-term goals to prepare her for a patient-oriented research career. Short-term goals include obtaining didactic training and mentoring in several "core" areas that have been chosen to deepen her existing skills and to expand her skills into new areas. The applicant's long-term goals are to develop a programmatic line of research that is focused on developing innovative treatments for anxiety disorders in childhood and adolescence, and their most commonly comorbid conditions, as well as to launch a highly productive career as a clinical scientist. A formal research plan is proposed to investigate emotional disorders in adolescence, focusing specifically on anxiety disorders and unipolar mood disorders. Despite theory and research that suggests these disorders may share common biological and psychological vulnerabilities, demonstrate high comorbidity with one another, and evidence a potentially chronic impact on development, there have been few treatment studies investigating the efficacy of a single protocol with the applicability to treat this array of conditions in adolescence. The primary goal of the proposed research plan is to develop and apply a novel treatment for adolescents with emotional disorders, based on efficacious treatments for anxiety and depression in youth and an existent intervention for adults that unites fundamental treatment components appropriate for intervention with wide range of emotional disorders. The main goals of this project are: (1) to create a new treatment, entitled Adolescent Depression and Anxiety Protocol Treatment (ADAPT), for adolescents exhibiting a range of emotional disorders; (2) to conduct a small open trial using ADAPT with 15 adolescents evidencing anxiety and/or unipolar mood disorders; and, (3) to establish an initial effect size for the ADAPT program in a pilot study with 60 adolescents with anxiety and/or unipolar mood disorders and to assess maintenance of change at 3 and 6 months following treatment. The resulting treatment may have a far-reaching impact via dissemination to community providers treating adolescents with anxiety and depression by virtue of its relative consistency in format, combined with its breadth of application.