Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine

描述（由申请人提供）：该提案展示了弗吉尼亚大学（UVA）为NHLBI/NINDS赞助的心血管医学心胸外科研究网络做出重大贡献的巨大潜力。与我们的联盟机构Inova Fairfax医院和Carilion Roanoke纪念医院一起，我们的团队平均每年进行3000例成人心血管手术（仅在弗吉尼亚大学就有800例），这些手术将在网络协议中招募。该调查小组由欧文·l·克朗（Irving L. Kron）博士领导，他是一名心胸血管外科医生，也是弗吉尼亚大学外科系主任。他曾多次担任与心胸研究和教育相关的国家领导职务。他还获得了NHLBI的长期研究资助。联合首席研究员Karen C. Johnston博士是全国公认的血管认证神经科医生，拥有NINDS资助和临床试验、神经保护和结果研究方面的专业知识。此外，John Dent博士是全国知名的心脏病专家，在超声心动图方面提供特定的专业知识，因为它适用于瓣膜性心脏病。心血管外科、中风神经病学/神经学结果和心脏病学的独特组合，加上庞大的城市和农村人口基础，保证了UVA将为心血管医学心胸外科调查网络做出实质性和新颖的贡献。我们的具体目标包括：

DESCRIPTION (provided by applicant): This proposal demonstrates the great potential of the University of Virginia (UVA) to make major contributions to the NHLBI/NINDS sponsored Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Together with our consortium institutions, Inova Fairfax Hospital and Carilion Roanoke Memorial Hospital, our team performs an average of 3,000 adult cardiovascular surgical procedures annually (> 800 cases at UVA alone) which would be available for recruitment in Network protocols. The investigative group is led by Dr. Irving L. Kron, a cardiothoracic and vascular surgeon who is Chair of the Department of Surgery at UVA. He has been involved in multiple national leadership roles that relate to cardiothoracic research and education. He also has received long term research funding from NHLBI. The co-principal investigator is Dr. Karen C. Johnston, a nationally recognized vascular certified neurologist with NINDS funding and expertise in clinical trials, neuroprotection and outcomes research. Additionally, Dr. John Dent, a nationally known cardiologist, provides specific expertise in echocardiography as it applies to valvular heart disease. The unique mix of cardiovascular surgery, stroke neurology/neurological outcomes, and cardiology in addition to a large urban and rural population base guarantees that UVA will make substantive and novel contributions to the Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Our specific aims include: Specific Aim 1: To describe the experience, expertise and collaborative nature of UVA that will substantially contribute to the success of a Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine. Specific Aim 2: To demonstrate the proof of concept for a subvalvular approach for ischemic mitral valve regurgitation by repositioning the posterior papillary muscle of the mitral valve in a phase II randomized clinical trial. Specific Aim 3: To demonstrate the efficacy and safety of perioperative Atorvastatin therapy for patients undergoing major cardiac surgery in a randomized, blinded, controlled phase III trial. Preliminary data have suggested that this intervention will reduce mortality and morbidity in cardiac surgical patients even without atherosclerosis. (End of Abstract)