Triglycerides and cardiovascular disease: meta-analysis of individual data on 600 000 participants in 60 studies

甘油三酯是一种特殊的脂肪，在吸烟、吃高脂肪食物和有高血压的人的血液中增加。广泛可用的测试，可以测量血液甘油三酯浓度经常用于帮助预测心脏病发作的风险。尽管在过去的50年里已经进行了数十项关于甘油三酯和心脏病发作风险的长期研究，但仍然不确定这些血脂的测量是否真的值得，或者它们是否可能是心脏病发作的原因。个别研究往往规模太小，以前对这些研究的审查不够详细，无法得出明确的结果。为了帮助提供关于甘油三酯与心脏病相关性的更可靠的证据，我们将对来自约60项长期研究的约60万人的甘油三酯和未来心脏病发作风险的现有研究进行详细的综合分析。以前，这种方法有助于澄清关于心脏病发作的其他预测因素（如血压）的证据，它也应该对甘油三酯这样做。

Triglycerides are specific fats that are increased in the blood of people who smoke, eat fatty foods and have high blood pressure. Widely available tests that can measure blood triglycerides concentrations are frequently used to help predict heart attack risk. Although dozens of long-term studies of triglycerides and heart attack risk have been conducted over the past 50 years, it is still uncertain whether measurement of these blood fats is actually worthwhile or whether they are likely to be causative of heart attacks. Individual studies have tended to be too small, and previous reviews of such studies have been insufficiently detailed to give clear results. To help provide much more reliable evidence about the relevance of triglycerides to heart disease, we will conduct detailed combined analyses of the available studies of triglycerides and future heart attack risk in a total of about 600 000 individuals from about 60 long-term studies. Previously, this approach helped clarify the evidence about other predictors of heart attack (such as blood pressure) and it should also do so for triglycerides.